It’s closely related to cabbage, Brussels sprouts, kale and cauliflower — all edible plants collectively referred to as cruciferous vegetables. .

BROCCOLI SPROUT: Overview, Uses, Side Effects, Precautions

Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells.Prostate 2009;69(2):181-190.Brooks JD, Paton VG, Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane.Clarke JD, Dashwood RH, Ho E.

Multi-targeted prevention of cancer by sulforaphane.Dashwood RH, Ho E. Dietary histone deacetylase inhibitors: from cells to mice to man.Dinkova-Kostova AT, Fahey JW, Benedict AL, et al. Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.Dinkova-Kostova AT, Jenkins SN, Fahey JW, et al.

Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts.Chem Res Toxicol 2008;21(10):1991-1996.Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.J Agric Food Chem 2001;49:2679-83.Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells.Clin Cancer Res 2010;16(9):2580-2590.Heating decreases epithiospecifier protein activity and increases sulforaphane formation in broccoli.J Agric Food Chem 2010;58(11):6672-6677.Cancer Res 2008;68(5):1593-1600.Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one-week intake of broccoli sprouts.A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.Cancer Res 2004;64(16):5767-5774.J Agric Food Chem 2006;54(7):2479-2483.on inoculated broccoli seeds and effects of irradiation on broccoli sprout keeping quality and seed viability.Shapiro TA, Fahey JW, Dinkova-Kostova AT, et al.

Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.Nutr Cancer 2006;55(1):53-62.Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.Tang L, Zhang Y, Jobson HE, et al.Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract.Quantitative determination of intact glucosinolates in broccoli, broccoli sprouts, Brussels sprouts, and cauliflower by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.Mol Cancer 2010;9:189.Yanaka A, Fahey JW, Fukumoto A, et al. Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.Cancer Prev Res (Phila) 2009;2(4):353-360.Zhang Y, Munday R, Jobson HE, et al.J Agric Food Chem 2006;54(25):9370-9376.Brown RH, Reynolds C, Brooker A, Talalay P, Fahey JW.Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways.Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli.Nutr Cancer 2000;38:168-78.View abstract.Chem Res Toxicol 2008;21(10):1991-1996.Fahey JW, Zhang Y, Talalay P.

Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.Effects of dietary broccoli on human drug metabolising activity.Cancer Res 2008;68(5):1593-1600.on inoculated broccoli seeds and effects of irradiation on broccoli sprout keeping quality and seed viability.Shapiro TA, Fahey JW, Dinkova-Kostova AT, et al. Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.Nutr Cancer 2006;55(1):53-62.Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.Prostate.Yanaka A, Fahey JW, Fukumoto A, et al.

Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.Cancer Prev Res (Phila) 2009;2(4):353-360.Yoshida K, Ushida Y, Ishijima T, et al.Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury. .

Sulforaphane: Benefits, Side Effects, and Food Sources

Sulforaphane is a natural plant compound found in many cruciferous vegetables like broccoli, cabbage, cauliflower, and kale.Sulforaphane is a sulfur-rich compound found in cruciferous vegetables like broccoli, bok choy, and cabbage.Myrosinase enzymes are only released and activated when a plant is damaged.Summary Sulforaphane is a naturally occurring compound in cruciferous vegetables like broccoli, cabbage, and kale.Potential Benefits Animal, test-tube, and human studies have indicated that sulforaphane may offer a number of health benefits.Sulforaphane has been shown to have anticancer properties in a number of test-tube and animal studies, reducing both the size and number of various types of cancer cells ( 5 , 6 , 7 ).May Support Heart Health Both test-tube and animal studies show that sulforaphane may boost heart health in a number of ways ( 13 ).A 12-week study in 97 people with type 2 diabetes examined how consuming broccoli sprout extract — equivalent to 150 µmol of sulforaphane — daily affected blood sugar levels ( 17 ).Sulforaphane’s beneficial effect on blood sugar levels are supported by animal studies as well ( 18 , 19 ).Other Health Benefits Studies show that sulforaphane may have other health benefits as well: May treat certain symptoms of autism.In a 4-week study in 48 adults, eating 20 grams of sulforaphane-rich broccoli sprouts improved symptoms of constipation.Summary Sulforaphane has been associated with various health benefits and may beneficially affect cancer, heart disease, diabetes, and digestion.These supplements are typically made from broccoli or broccoli sprout extract and generally concentrated, containing more sulforaphane than what’s naturally found in food.Sulforaphane supplements are available on the market as well.To increase your intake of sulforaphane, include more of the following vegetables in your diet: broccoli sprouts.Summary Sulforaphane can be found in cruciferous vegetables like broccoli, kale, cabbage, and watercress. .

Broccoli Compound May Combat COPD

In chronic obstructive pulmonary disease (COPD), damage to immune cells limits the lungs’ ability to fight off bacterial infections.In patients with COPD, immune cells called macrophages lose their ability to engulf and remove bacteria, making the lungs more vulnerable to infection.Shyam Biswal and Robert Wise, investigated why macrophages don’t work properly in COPD patients.Oxidative stress occurs when the body can’t effectively neutralize damaging compounds called peroxides and free radicals.Sulforaphane treatment also boosted the ability of cultured macrophages to clear 2 of the major types of bacteria that infect COPD patients.Experiments in mouse and human cells revealed that sulforaphane, through Nrf2, increases levels of a receptor called MARCO on macrophages.The researchers also gave human COPD patients broccoli sprout extract enriched with sulforaphane for 2 weeks. .

Broccoli Extract Benefits, Side Effects and Dosage

What is Broccoli Extract?If you’re like most people, the answer is probably “no.” Whether you don’t have time to cook broccoli, or you simply don’t like its taste or texture, broccoli is nonetheless one of the healthiest foods out there.Broccoli is high in fiber, great for helping digestion, and also contains a compound called sulforaphane, which stimulates enzyme production in the body.Broccoli extract contains the bioactive compounds found in the florets and stems of this healthful cruciferous vegetable.Benefits of Broccoli Extract.Another study showed that consuming sulforaphane can help regulate key enzymes and immune system reactions that protect the body from cancer (x).Broccoli extract can improve digestion and intestinal health.Broccoli extract may even be better than fresh broccoli for those with digestive problems.Some people experience pain, bloating, gas and other symptoms when they eat foods with high fiber.Broccoli extract can help stop inflammation at its source.Boosts Brain Health.Vitamin K is in very few foods, but it’s key to maintaining healthy brain function, and may even prevent diseases like dementia and Alzheimer’s (x).Along with vitamin K, the choline in broccoli can help maintain and improve cognition.You can also mix it with other vegetables for a nutrient boost.Broccoli and broccoli extract are safe to eat for healthy adults.Mix broccoli extract powder in pesto, marinara or even salad dressing for a nutritious boost to meals. .

Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2

In our previous studies, we have shown the protection provided by SFN against DCM via up-regulation of Nrf2 expression and transcription activation, thus, preventing oxidative stress and damage in both the streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM)20 and the T2DM model29.Our previous studies29,31,33,34 had revealed the preventive effect of SFN on diabetes-induced organ damage in a mouse model of T2DM that was induced by high fat diet (HFD) feeding plus small dose of STZ.However, the ability of human gut microflora to hydrolyze glucoraphanin and release sulforaphane for absorption in the large intestine varies greatly among individuals26,39.It is worth mentioned that broccoli sprout preparations have been approved to be clinically safe to use in healthy volunteers25,26,27,28 for the prevention of chronic obstructive pulmonary disease10, asthma23,24 and even cancers41,42,43.One recent example is a study involving seven patients with schizophrenia that have completed a trial with 3 tablets of SFN, consisting of 30 mg of SFN-glucosinolate per day, for 8 weeks.Taking these findings together, BSE, along with broccoli’s other products, has great potential for use in the clinical realm for the prevention and treatment of a variety of health conditions.In summary, we have investigated and showed that, like SFN, BSE can prevent DCM in a transgenic T2DM mouse model via activation of Nrf2 by inhibiting diabetes-induced cardiac oxidative stress and damage as well as inflammation. .

The Benefits of Broccoli Extract

In addition to the vitamin A and fiber it supplies in abundance, broccoli contains an unusual compound -- sulforaphane -- that may reduce your risk of certain types of cancer, lower your cholesterol and combat ulcer-causing Helicobacter pylori bacteria in your digestive system.The journal "Cancer Research" reported in 2008 that concentrated extract from broccoli sprouts halved the incidence of bladder tumors in an animal study.The animals showed lower cholesterol levels.Animal studies do not always correspond to similar benefits for humans, so researchers don't yet know if human participants will also enjoy lower cholesterol levels on broccoli extract.Broccoli extract may have a similar antibiotic effect on the microbe, according to a small study published in "Cancer Prevention Research.". .

Chemical Derived from Broccoli Sprouts Shows Promise in Treating

Broccoli sprouts Johns Hopkins Medicine.Researchers say that many of those taking sulforaphane substantially improved in several aspects of their behavior during treatment.Its behavioral symptoms, such as poor social interaction and verbal communication, are well known and were first described 70 years ago by Leo Kanner, M.D., the founder of pediatric psychiatry at The Johns Hopkins University.He says that studies show that the cells of those with ASD often have high levels of oxidative stress, the buildup of harmful, unintended byproducts from the cell’s use of oxygen that can cause inflammation, damage DNA, and lead to cancer and other chronic diseases.In 2007, Zimmerman, a principal collaborator in the current study, tested this anecdotal trend clinically and found it to be true, though a mechanism for the fever effect was not identified.After 18 weeks of treatment, according to the CGI-I scale, 46, 54 and 42 percent of sulforaphane recipients experienced noticeable improvements in social interaction, aberrant behaviors and verbal communication, respectively.They found out later that all 13 had been taking sulforaphane, which is half of the treatment group.Talalay cautions that the levels of sulforaphane precursors present in different varieties of broccoli are highly variable.These studies were designed at The Johns Hopkins University by Andrew Zimmerman in collaboration with Paul Talalay and Kirby Smith. .

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