Abdulah R, Faried A, Kobayashi K, et al. Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells.Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells.Brooks JD, Paton VG, Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane.Clarke JD, Dashwood RH, Ho E.

Multi-targeted prevention of cancer by sulforaphane.Dashwood RH, Ho E. Dietary histone deacetylase inhibitors: from cells to mice to man.Dinkova-Kostova AT, Fahey JW, Benedict AL, et al.

Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.Dinkova-Kostova AT, Jenkins SN, Fahey JW, et al. Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts.Egner PA, Kensler TW, Chen JG, et al. Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry.Fahey JW, Haristoy X, Dolan PM, et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.Fahey JW, Zhang Y, Talalay P.

Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.Comparison of the stress response of Listeria monocytogenes strains with sprout colonization.Haristoy X, Angioi-Duprez K, Duprez A, Lozniewski A. Efficacy of sulforaphane in eradicating Helicobacter pylori in human gastric xenografts implanted in nude mice.Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China.Kerns ML, DePianto D, Dinkova-Kostova AT, Talalay P, Coulombe PA.

Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex.Keum YS, Khor TO, Lin W, et al. Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway.Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells.Lee, S. Y., Shin, Y.

W., and Hahm, K. B. Phytoceuticals: mighty but ignored weapons against Helicobacter pylori infection.Li Y, Zhang T, Korkaya H, et al.

Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells.Heating decreases epithiospecifier protein activity and increases sulforaphane formation in broccoli.Moon JK, Kim JR, Ahn YJ, Shibamoto T. Analysis and anti-Helicobacter activity of sulforaphane and related compounds present in broccoli ( Brassica oleracea L.) sprouts.Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one-week intake of broccoli sprouts.Myzak MC, Karplus PA, Chung FL, Dashwood RH.Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds.Riedl MA, Saxon A, Diaz-Sanchez D.

Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway.Shapiro TA, Fahey JW, Dinkova-Kostova AT, et al. Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.Talalay P, Fahey JW, Healy ZR, et al.

Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation.Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract.Tanito M, Masutani H, Kim YC, et al. Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice.West L, Tsui I, Haas G.

Single column approach for the liquid chromatographic separation of polar and non-polar glucosinolates from broccoli sprouts and seeds.Wu L, Noyan Ashraf MH, Facci M, et al. Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system.Yanaka A, Fahey JW, Fukumoto A, et al.

Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.Yanaka A, Zhang S, Tauchi M, et al. Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress.Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli.Egner PA, Kensler TW, Chen JG, et al.

Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry.Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.Comparison of the stress response of Listeria monocytogenes strains with sprout colonization.Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers.Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China.Keum YS, Khor TO, Lin W, et al. Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway.Kikuchi M, Ushida Y, Shiozawa H, et al.

Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects.Shapiro TA, Fahey JW, Dinkova-Kostova AT, et al. Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P.

Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.Shiina A, Kanahara N, Sasaki T, et al. An open study of sulforaphane-rich broccoli sprout extract in patients with schizophrenia.van Die MD, Williams SG, Emery J, et al.

A placebo-controlled double-blinded randomized pilot study of combination phytotherapy in biochemically recurrent prostate cancer.West L, Tsui I, Haas G. Single column approach for the liquid chromatographic separation of polar and non-polar glucosinolates from broccoli sprouts and seeds.Yanaka A, Fahey JW, Fukumoto A, et al.

Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury. .

How Do Broccoli Supplements Compare to Sprouts?

Researchers compared six capsules a day to a cup of broccoli sprouts.In the video, Broccoli: Sprouts vs.Supplements, you can see the spike in broccoli phytonutrients in the bloodstream of those eating sprouts.See: How Much Broccoli is Too Much? .

Vitacost Broccoli Sprout Extract Herbal Supplement Capsules

What is Broccoli Sprout Extract?Broccoli Sprout Extract is a high-quality broccoli (Brassica oleracea) sprout extract, standardized to 6% glucosinolates and 0.3% sulforaphane, the active constituents found in cruciferous vegetables.Supplies 1,000 mg of broccoli sprout extract per 2-capsule serving. .

Top 14 Health Benefits of Broccoli

It’s closely related to cabbage, Brussels sprouts, kale and cauliflower — all edible plants collectively referred to as cruciferous vegetables. .

Sulforaphane: Uses, Benefits, and Side Effects

Sulforaphane is a natural plant compound derived from cruciferous vegetables, such as broccoli and Brussels sprouts.After 12 months of eating a portion of broccoli soup each week, an inverse dose-dependent association was observed between the test group and prostate cancer progression.A 2016 study looked at the association between cruciferous vegetable intake and certain tumor biomarkers among 54 people scheduled for breast biopsies after abnormal mammogram findings.The study found that total cruciferous vegetable intake was associated with decreased cell growth in breast tissue, though there are other compounds in broccoli that may have contributed to these findings..In 2014 a placebo-controlled, double-blind, randomized study was published that examined sulforaphane treatment in 44 young men with autism spectrum disorder..In 2015 a paper was published that reviewed evidence from clinical studies and animal experiments relating to the possible ways in which sulforaphane is protective against cardiovascular disease..Though sulforaphane seems to be well tolerated with minimal side effects, there is not enough quality research to know if it is safe to take by mouth as a medicine, especially in high doses and for long periods of time.Sulforaphane supplements are most commonly available in the form of tablets, capsules or powder, but can also be bought as a liquid.There are no daily intake recommendations for sulforaphane and supplement brands vary widely in how much they suggest taking.Although there is wide availability of sulforaphane in supplemental form, more research is needed to determine the ideal dose, safety, and effectiveness.Simply reading the label may not provide enough information to make a well-informed buying decision on supplements such as sulforaphane.They can guide you toward the best dosage for your needs and recommend a trustworthy product certified by a third party to ensure quality, such as the U.S. Pharmacopeia, NSF International, or Consumer Lab.Because of this, if you want to take full advantage of the sulforaphane content in your cruciferous vegetables, it’s best to avoid boiling or microwaving them. .

Cancer-busting broccoli sprout pills? It's a thing.

“Toxins are fat-soluble, so they go into the body and become trapped,” Kensler said.To detoxify harmful agents, the body attaches what Kensler calls a “hitch,” a molecular chain, that can also make the chemical more reactive.Kensler’s broccoli bombs — packed with soon-to-be-sulforaphane — target our body’s multifaceted cellular defense mechanism, the Keap1-Nrf2 pathway and the enzymes it regulates.These phytochemicals also provide a broad-based mechanism, Kensler said, one that can “work for airborne, food-borne and waterborne pollutants.”.“Broccoli tea doesn’t taste all that good,” Kensler said of the beverage they brewed for some of their trials.“Most people find it obnoxiously bitter so we worked with a sensory company to mask the taste and it worked.According to their analysis, Kensler and colleagues were able to increase the elimination of carcinogens from test subjects’ bodies by 67%, which he said, “should make a difference.”.For their last clinical trial, which ended in December 2019, they worked with a vendor to manufacture tablets from milled and powdered broccoli seeds mixed with freeze-dried broccoli sprouts.Go online and you’ll find an assortment of products with glucoraphanin, myrosinase and sulforaphane.He said the vendor who created the broccoli sprout tablet for the trial used rigorous quality control through sourcing and manufacturing and distribution. .

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