Consumption of a cholesterol-rich diet led to the formation of cholesterol gallstones (CGS) in mice, but supplementation of this diet with garlic and onion reduced the incidence of the gallstones, according to findings published online in the British Journal of Nutrition.The incidence of gallstones in the latter group was found to be reduced by 15 to 30 per cent, said the researchers. .
Garlic and Gallstones
Used medicinally for thousands of years, more recently garlic has been studied for treating health problems such as atherosclerosis and high blood pressure.Current studies of garlic's effects on gallstones show promising results, but more research is necessary.Solidification occurs when concentrations of cholesterol or bilirubin in the bile become too high, and they precipitate out of solution and form crystals.Solidification occurs when concentrations of cholesterol or bilirubin in the bile become too high, and they precipitate out of solution and form crystals.A 2009 study in the "British Journal of Nutrition" found similar results, showing mice fed garlic and onion produced less biliary cholesterol and more bile 2.Together, these sulfur-containing compounds may be responsible for garlic's beneficial effects on heart health and cancer, reports the University of Maryland Medical Center 3.Together, these sulfur-containing compounds may be responsible for garlic's beneficial effects on heart health and cancer, reports the University of Maryland Medical Center 3.As a food supplement, the University of Maryland Medical Center recommends adults consume 2 to 4 grams of fresh, minced garlic per day 3. .
The Benefits of Cayenne & Garlic for Gallstones
A study on mice conducted by the Department of Biochemistry and Nutrition, Central Food Technological Research Institute (CSIR) in India found that dietary garlic and onion reduce the incidence of atherogenic diet-induced cholesterol gallstones. .
Dietary garlic and onion reduce the incidence of atherogenic diet
The pathogenic conditions that generally precede the occurrence of CGS are lithogenic bile, gallbladder stasis and short nucleation time.But the molecular origins of altered secretion rates of biliary lipids in human cholesterol cholelithiasis remain unknown.Whether defects exist in hepatic lipid regulatory enzymes, responsible for cholesterol and bile acid biosynthesis, is not clear.Spices or their active principles like capsaicin from red pepper, curcumin from turmeric, fenugreek, garlic and onion have been widely documented for their hypocholesterolaemic as well as lipid-lowering properties(Reference Srinivasan, Sambaiah and Chandrasekhara9).Spices are prone to lose their bioactive principles during food processing conditions such as cooking(Reference Suresh, Manjunatha and Srinivasan12).In this context, the antilithogenic potential of garlic and onion was evaluated both in their raw and heat-processed forms during LG diet-induced CGS formation in mice.Fatty acids were analysed as methyl esters prepared using boron trifluoride in methanol as described by Morrison & Smith ( Reference Morrison and Smith 22 ) and analysed by GC (Shimadzu 14B, fitted with free induction decay) using a fused silica capillary column (25 m × 0·25 mm; Parma bond FFAP-DF-0·25; Machery-Nagel GmbH Co., Duren, Germany).The other organs were quickly excised, washed with ice-cold saline and blotted dry, weighed and stored at − 20°C till further analysis.The gallbladders were evaluated for CGS under magnifying lens for the presence of gallstones by four individuals unaware of dietary treatments.Dietary onion (either heat-processed or raw) and garlic (heat-processed) appeared to counter the decrease in oleic acid content by 10, 18 and 20 %, respectively, compared to the LG diet group.The biliary lipid profile in animals fed Allium spices in addition to LG diet is given in Table 5 .Garlic (raw) and onion (heat-processed) feeding along with LG diet countered this increase in phospholipid content by 13 and 26 %, respectively.Liver lipid profile in animals fed garlic or onion during experimental CGS induction is given in Table 4 .The serum lipid profile in animals fed garlic or onion during experimental induction of CGS is presented in Table 3 .The LG diet feeding caused hypercholesterolaemia where serum cholesterol increased 2·4-fold compared to control animals.Animals fed with LG diet supplemented with garlic or onion showed significant reduction in the incidence of CGS.The present investigation used the well-studied mouse model for the induction of CGS by feeding high-cholesterol diet(Reference Tepperman, Cladwell and Tepperman26).Allium spices, garlic and onion, have been known to possess health beneficial hypolipidaemic, hypocholesterolaemic and hydrocholagoguic influences(Reference Srinivasan, Sambaiah and Chandrasekhara9).Cooking or roasting alters the nature of many food constituents such as starches and proteins by changing their physical, chemical and nutritional properties.Earlier studies in our laboratory with rats have indicated that 2 % dietary onion or 0·5 % dietary garlic powder produced significant increase in bile volume and in the secretion of biliary bile acids presumably due to higher rate of conversion from cholesterol(Reference Sambaiah and Srinivasan29, Reference Platel and Srinivasan30).These dietary doses of the two Allium spices were hence examined in the present study for an antilithogenic influence during high cholesterol feeding in experimental mice.These doses of garlic and onion roughly correspond to five times what is generally consumed by the population in India(Reference Thimmayamma, Rao and Radhaiah32).Feeding of LG diet significantly increased liver weight due to high cholesterol deposition and higher TAG content.Feeding of garlic and onion partially countered this increase in liver weights obviously by correcting the alterations in the hepatic lipid profile.The LG diet feeding in the present study increased the hepatic cholesterol, a significant part of which is secreted into bile.The inclusion of Allium spices in the diet reduced the incidence of CGS formation and is evident where the CSI < 1.In the present study, LG diet feeding significantly increased C/PL ratio which paralleled the elevated CSI in bile.With this increased ratio, the vesicles become unstable and tend to nucleate cholesterol(Reference Roslyn, Doty and Pitt40).In fact, it was demonstrated that deoxycholic acid is highly hydrophobic and was associated with human cholelithiasis(Reference Afdhal and Smith41).It is suggested that glycine-conjugated bile acids are more hydrophobic which are lithogenic in nature, while taurine conjugates have opposite effects.Hepatic HMG-CoA reductase activity was diminished by LG diet due to negative feedback inhibition.Earlier, we have reported that cholesterol 7α-hydroxylase activity in rats was increased by feeding spices(Reference Srinivasan and Sambaiah45).Feeding garlic or onion significantly brought down the cholesterol content in serum and liver and it was evident in the lowered CSI values and decreased CGS occurrence.The spice diets significantly brought down this ratio, which was reflected in the lower CSI and CGS occurrence.The sulphur compounds, alliin and allicin of garlic, and propenyl sulphides present in onion, are presumably responsible for the hypocholesterolaemic influences of the parent spices(Reference Srinivasan, Sambaiah and Chandrasekhara9).The antilithogenicity of garlic and onion is attributable primarily to this hypocholesterolaemic influence produced by these bioactive sulphur compounds.The present study clearly demonstrated that feeding of garlic and onion inhibited the formation of CGS in mice during experimental induction by decreasing the cholesterol content in serum, liver and bile.The present study also showed that heat processing of these Allium spices does not significantly compromise the antilithogenic influence, and in fact heat-processed onion was even more effective than its raw form in alleviating the incidence of CGS in mice.The dietary dosage of garlic and onion evaluated here which is roughly five times what is normally consumed can probably be tolerated to derive this health benefit.Although a combination of phenotypic expression of genetic traits predisposes to stone formation, the higher prevalence of CGS disease in the USA, Chile and Europe (Sweden, Germany and Austria) relative to Asian and African countries and the very high prevalence in ethnic groups such as American Indians and Chilean Mapuche Indians could probably be mitigated by the liberal consumption of these Allium spices. .
Does Lemon Juice or Olive Oil Help With Gallstones?
While you may see a fair amount backing this treatment, the medical community does not recognize lemon juice as a viable treatment for passing or dissolving gallstones, and instead recommends alternative treatments if gallstone symptoms are severe.What Are Gallstones?Gallstones are hardened deposits of digestive fluid that can form in the gallbladder, according to the Mayo Clinic.There are two different types of gallstones, according to the Mayo Clinic: cholesterol gallstones and pigment gallstones.Cholesterol gallstones tend to be yellow in color.Pain in your right shoulder.Nausea or vomiting.Although drinking a large quantity of olive oil and lemon juice is not inherently dangerous, there are risks you should consider before choosing to conduct a gallbladder cleanse.So-called gallbladder cleanses, flushes and remedies involving lemon juice advise drinking some kind of juice combination to breakdown gallstones.Another seemingly popular gallbladder cleanse is once that involves olive oil and lemon juice for a gallbladder flush recipe.Proponents of these types of recipes claim that gallbladder cleansing helps break up gallstones and stimulates the gallbladder to release them in stool, per the Mayo Clinic.Some people may experience the following when attempting this type of cleanse, per the Mayo Clinic:.Abdominal pain.Most people with gallstones that don't cause symptoms will never need treatment of any kind, per the Mayo Clinic.Your doctor may recommend you be extra mindful of possible symptoms, like an intensifying pain in your right abdomen. .
What Are the Best Foods To Eat When You Have Gallstones?
What are gallstones?Gallstones are hard deposits that can form in your gallbladder which can potentially block the flow of bile and cause serious symptoms.During the digestion process, your gallbladder releases bile through a duct into the small intestines.Other problems with the gallbladder can include gallbladder cancer, chronic gallbladder disease, cholecystitis (inflammation of the gallbladder), and perforated gallbladder.Around 80 percent of people have what is called “silent gallstones,” meaning they never experienced any pain or other symptoms .However, if a gallstone gets lodged in a bile duct and causes a blockage, it can lead to the following symptoms:.It may be caused by too much cholesterol or bilirubin in your bile, which may cause gallstones if the gallbladder is unable to break down the excess. .