He prescribed garlic to treat a variety of medical conditions — and modern science has confirmed many of these beneficial health effects.Garlic grows in many parts of the world and is a popular ingredient in cooking, due to its strong smell and delicious taste.Its use was well documented by many major civilizations, including the Egyptians, Babylonians, Greeks, Romans, and Chinese ( 1 ).Other compounds that may play a role in garlic’s health benefits include diallyl disulfide and s-allyl cysteine ( 3 ).Summary Garlic is a plant in the onion family that’s grown for its distinctive taste and health benefits.A large, 12-week study found that a daily garlic supplement reduced the number of colds by 63% compared with a placebo ( 5 ).Summary Garlic supplements may help prevent and reduce the severity of illnesses like the flu and common cold, but more research needs to be done before any conclusions can be made.The active compounds in garlic can reduce blood pressure Cardiovascular diseases like heart attack and stroke are responsible for more deaths than almost any other condition ( 8 ).In one study, 600–1,500 mg of aged garlic extract were just as effective as the drug Atenolol at reducing blood pressure over a 24-week period ( 12 ).Garlic contains antioxidants that may help prevent Alzheimer’s disease and dementia Oxidative damage from free radicals contributes to the aging process.But given the beneficial effects on important risk factors like blood pressure, it makes sense that garlic could help you live longer.The fact that it can fight infectious diseases is also an important factor, because these are common causes of death, especially in the elderly or people with dysfunctional immune systems ( 23 ).Summary Garlic has known beneficial effects on common causes of chronic disease, so it makes sense that it could also help you live longer.It was traditionally used in ancient cultures to reduce fatigue and improve the work capacity of laborers.Summary Garlic may improve physical performance in lab animals and people with heart disease.Summary Garlic was shown to significantly reduce lead toxicity and related symptoms in one study.However, rodent studies have shown that it can minimize bone loss by increasing estrogen in females ( 27 , 28 , 29 , 30 ).Summary Garlic appears to have some benefits for bone health by increasing estrogen levels in females, but more human studies are needed.Garlic is easy to include in your diet and adds flavor The last one is not a health benefit but is still important. .
GARLIC: Overview, Uses, Side Effects, Precautions, Interactions
Garlic for peripheral arterial occlusive disease (Cochrane Review).Kabasakal, L., Sehirli, O., Cetinel, S., Cikler, E., Gedik, N., and Sener, G. Protective effect of aqueous garlic extract against renal ischemia/reperfusion injury in rats.Kandziora J. Blutdruck and lipidsenkende Wirkung eines Knoblauch-praparates in kombination mit einem Diuretikum.Kannar D. Clinical evaluation of Australian based garlic and its combination with inulin in mild and moderate hyperlipidaemia [dissertation] .Kannar, D., Wattanapenpaiboon, N., Savige, G. S., and Wahlqvist, M. L.
Hypocholesterolemic effect of an enteric-coated garlic supplement.Keiss, H. P., Dirsch, V. M., Hartung, T., Haffner, T., Trueman, L., Auger, J., Kahane, R., and Vollmar, A. M. Garlic (Allium sativum L.) modulates cytokine expression in lipopolysaccharide-activated human blood thereby inhibiting NF-kappaB activity.Khodavandi, A., Alizadeh, F., Harmal, N. S., Sidik, S.
M., Othman, F., Sekawi, Z., Jahromi, M. A., Ng, K. P., and Chong, P.
P. Comparison between efficacy of allicin and fluconazole against Candida albicans in vitro and in a systemic candidiasis mouse model.Kianoush, S., Balali-Mood, M., Mousavi, S.
R., Moradi, V., Sadeghi, M., Dadpour, B., Rajabi, O., and Shakeri, M. T.
Comparison of therapeutic effects of garlic and d-Penicillamine in patients with chronic occupational lead poisoning.Effects of garlic on blood fluidity and fibrinolytic activity: a randomised, placebo-controlled, double-blind study.Kim, J. Y. and Kwon, O. Garlic intake and cancer risk: an analysis using the Food and Drug Administration's evidence-based review system for the scientific evaluation of health claims.Knox, J.
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Helicobacter pylori eradication with beta carotene, ascorbic acid and allicin.Kojuri, J., Vosoughi, A. R., and Akrami, M. Effects of anethum graveolens and garlic on lipid profile in hyperlipidemic patients.Koscielny, J., Schmitt, R., Radtke, H., Latza, R., and Kiesewetter, H. Garlic study vindicated by official investigation.Ku DD, Abdel-Razek TT, Dai J, and et al. Mechanisms of garlic induced pulmonary vasorelaxation: role of allicin.Kumar, M. and Berwal, J.
S. Sensitivity of food pathogens to garlic (Allium sativum).Treatment of venous ulcers with the herbal-based ointment Herbadermal(R): a prospective non-randomized pilot study.Kweon, S., Park, K.
A., and Choi, H. Chemopreventive effect of garlic powder diet in diethylnitrosamine-induced rat hepatocarcinogenesis.Laing, M.
E., Barry, J., Buckley, A. M., and Murphy, G.
M. Immediate and delayed hypersensitivity reactions to food and latex in a chef.Larijani, V.
N., Ahmadi, N., Zeb, I., Khan, F., Flores, F., and Budoff, M. Beneficial effects of aged garlic extract and coenzyme Q10 on vascular elasticity and endothelial function: the FAITH randomized clinical trial.Lash, J.
P., Cardoso, L. R., Mesler, P. M., Walczak, D.
A., and Pollak, R. The effect of garlic on hypercholesterolemia in renal transplant patients.The effect of garlic oil on lipid peroxidation and blood cell counts of arsenic exposed albino mice.Lau BH, Lam F, Wang-Cheng R, and et al.
Effect of odor-modified garlic preparation on blood lipids.Leelarungrayub, N., Rattanapanone, V., Chanarat, N., and Gebicki, J. M. Quantitative evaluation of the antioxidant properties of garlic and shallot preparations.Lei, Y.
P., Chen, H. W., Sheen, L.
Y., and Lii, C. K.
Diallyl disulfide and diallyl trisulfide suppress oxidized LDL-induced vascular cell adhesion molecule and E-selectin expression through protein kinase A- and B-dependent signaling pathways.Lembo, G., Balato, N., Patruno, C., Auricchio, L., and Ayala, F. Allergic contact dermatitis due to garlic (Allium sativum).Levi, F., Franceschi, S., Negri, E., and La Vecchia, C.
Dietary factors and the risk of endometrial cancer.Levi, F., La Vecchia, C., Gulie, C., and Negri, E. Dietary factors and breast cancer risk in Vaud, Switzerland.Li, G., Shi, Z., Jia, H., Ju, J., Wang, X., Xia, Z., Qin, L., Ge, C., Xu, Y., Cheng, L., Chen, P., and Yuan, G. A clinical investigation on garlicin injectio for treatment of unstable angina pectoris and its actions on plasma endothelin and blood sugar levels.An intervention study to prevent gastric cancer by micro-selenium and large dose of allitridum.Li, M., Ciu, J. R., Ye, Y., Min, J.
M., Zhang, L. H., Wang, K., Gares, M., Cros, J., Wright, M., and Leung-Tack, J. Antitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule-interaction properties.Li, M., Min, J.
M., Cui, J. R., Zhang, L. H., Wang, K., Valette, A., Davrinche, C., Wright, M., and Leung-Tack, J.
Z-ajoene induces apoptosis of HL-60 cells: involvement of Bcl-2 cleavage.Lian Z, Jun-Ling M, and Wei-Dong L. A randomized multi-intervention trial to inhibit gastric cancer in Shandong (progress report).Lin, M. C., Wang, E.
J., Lee, C., Chin, K. T., Liu, D., Chiu, J.
F., and Kung, H. F. Garlic inhibits microsomal triglyceride transfer protein gene expression in human liver and intestinal cell lines and in rat intestine.Effect of supplementation with garlic oil on activity of Th1 and Th2 lymphocytes from rats.Liu, L.
and Yeh, Y. Y. Inhibition of cholesterol biosynthesis by organosulfur compounds derived from garlic.Lutomski J.
Klinische Untersuchungen zur therapeutischen Wirksamkeit von Ilha Rogoff Knobauchpillen mit Rutin.Ma, J. L., Zhang, L., Brown, L. M., Li, J. Y., Shen, L., Pan, K. F., Liu, W. D., Hu, Y., Han, Z.
X., Crystal-Mansour, S., Pee, D., Blot, W. J., Fraumeni, J.
F., Jr., You, W. C., and Gail, M.
H. Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality.Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats.Study on extending of the activity spectrum of a garlic preparation against candidiasis.Mansell P, Reckless PD, and Lloyd L.
The effect of dried garlic powder tablets on serum lipids in non-insulin dependent diabetic patients.Marsh, C. L., Torrey, R.
R., Woolley, J. L., Barker, G. R., and Lau, B.
H. Superiority of intravesical immunotherapy with Corynebacterium parvum and Allium sativum in control of murine bladder cancer.Alternative medicine -- a randomized double blind placebo-controlled clinical trial of garlic in hypercholesterolemic children [white diamond suit] 661.Reduced allergy rates in atopic eczema to contact allergens used in both skin products and foods: atopy and the 'hapten-atopy hypothesis'.A pilot study to determine the effectiveness of garlic oil capsules in the treatment of dyspeptic patients with Helicobacter pylori.Effects of garlic powder tablets on patients with hyperlipdaemia in Canadian clinical practice.Millen, A.
E., Subar, A. F., Graubard, B.
I., Peters, U., Hayes, R. B., Weissfeld, J.
L., Yokochi, L. A., and Ziegler, R.
G. Fruit and vegetable intake and prevalence of colorectal adenoma in a cancer screening trial.Mirunalini S, Ramachandran CR, and Nagini S.
Chemoprevention of experimental hamster buccal pouch carcinogenesis by garlic oil.Morioka, N., Sze, L. L., Morton, D. L., and Irie, R.
F. A protein fraction from aged garlic extract enhances cytotoxicity and proliferation of human lymphocytes mediated by interleukin-2 and concanavalin A.Mukherjee, M., Das, A. S., Das, D., Mukherjee, S., Mitra, S., and Mitra, C. Effects of garlic oil on postmenopausal osteoporosis using ovariectomized rats: comparison with the effects of lovastatin and 17beta-estradiol.on intestinal transference of calcium and its possible correlation with preservation of skeletal health in an ovariectomized rat model of osteoporosis.Nagae, S., Ushijima, M., Hatono, S., Imai, J., Kasuga, S., Matsuura, H., Itakura, Y., and Higashi, Y.
Pharmacokinetics of the garlic compound S-allylcysteine.Naganawa, R., Iwata, N., Ishikawa, K., Fukuda, H., Fujino, T., and Suzuki, A. Inhibition of microbial growth by ajoene, a sulfur-containing compound derived from garlic.Nagaraj, N.
S., Anilakumar, K. R., and Singh, O.
V. Diallyl disulfide causes caspase-dependent apoptosis in human cancer cells through a Bax-triggered mitochondrial pathway.Nahas, R.
and Balla, A. Complementary and alternative medicine for prevention and treatment of the common cold.Nantz, M. P., Rowe, C.
A., Muller, C. E., Creasy, R.
A., Stanilka, J. M., and Percival, S. S. Supplementation with aged garlic extract improves both NK and gammadelta-T cell function and reduces the severity of cold and flu symptoms: a randomized, double-blind, placebo-controlled nutrition intervention.Nishino, H., Iwashima, A., Itakura, Y., Matsuura, H., and Fuwa, T.
Antitumor-promoting activity of garlic extracts.A comparative study on the effectiveness of garlic with clofibrate in the treatment of hyperlipidemia.Numagami, Y. and Ohnishi, S.
T. S-allylcysteine inhibits free radical production, lipid peroxidation and neuronal damage in rat brain ischemia.Oi, Y., Kawada, T., Shishido, C., Wada, K., Kominato, Y., Nishimura, S., Ariga, T., and Iwai, K. Allyl-containing sulfides in garlic increase uncoupling protein content in brown adipose tissue, and noradrenaline and adrenaline secretion in rats.Omurtag, G.
Z., Guranlioglu, F. D., Sehirli, O., Arbak, S., Uslu, B., Gedik, N., and Sener, G. Protective effect of aqueous garlic extract against naphthalene-induced oxidative stress in mice.Orekhov A and Tertov V.
In vitro effect of garlic powder extract on lipid content in normal and atherosclerotic human aortic cells.Garlic powder tablets reduce atherogenicity of low density lipoprotein.Pai, S. T. and Platt, M.
W. Antifungal effects of Allium sativum (garlic) extract against the Aspergillus species involved in otomycosis.Papageorgiou, C., Corbet, J. P., Menezes-Brandao, F., Pecegueiro, M., and Benezra, C. Allergic contact dermatitis to garlic (Allium sativum L.).Parastoui K, Ravanshad Sh Mostafavi H Setoudeh Maram E. Effects of garlic tablet on blood sugar, plasma lipids and blood pressure in type 2 diabetic patients with hyperlipidemia.Parish, R. A., McIntire, S., and Heimbach, D.
M. Garlic burns: a naturopathic remedy gone awry.Pedraza-Chaverri, J., Maldonado, P. D., Medina-Campos, O.
N., Olivares-Corichi, I. M., Granados-Silvestre, M.
A., Hernandez-Pando, R., and Ibarra-Rubio, M. E. Garlic ameliorates gentamicin nephrotoxicity: relation to antioxidant enzymes.Effect of garlic on lipid profile and psychopathologic parameters in people with mild to moderate hypercholesterolemia.Pena, N., Auro, A., and Sumano, H.
A comparative trial of garlic, its extract and ammonium-potassium tartrate as anthelmintics in carp.Pinto, J. T.
and Rivlin, R. S. Antiproliferative effects of allium derivatives from garlic.Pinto, J.
T., Qiao, C., Xing, J., Rivlin, R. S., Protomastro, M.
L., Weissler, M. L., Tao, Y., Thaler, H., and Heston, W.
D. Effects of garlic thioallyl derivatives on growth, glutathione concentration, and polyamine formation of human prostate carcinoma cells in culture.Pittler, M.
H. and Ernst, E. Complementary therapies for peripheral arterial disease: systematic review.Plengvidhya, C., Sitprija, S., Chinayon, S., Pasatrat, S., and Tankeyoon, M. Effects of spray dried garlic preparation on primary hyperlipoproteinemia.Effect of dietary garlic (Allium Sativum) on the blood pressure in humans--a pilot study.Rahmani M, Tabari AK, Niaki MRK, and et al.
Effect of dried garlic supplementation on blood lipids in mild and moderate hypercholesterolemic patients.Rahmy, T. R. and Hemmaid, K. Z. Prophylactic action of garlic on the histological and histochemical patterns of hepatic and gastric tissues in rats injected with a snake venom.Rajan, T. V., Hein, M., Porte, P., and Wikel, S.
A double-blinded, placebo-controlled trial of garlic as a mosquito repellant: a preliminary study.Rapp, A., Grohmann, G., Oelzner, P., Uehleke, B., and Uhlemann, C. [Does garlic influence rheologic properties and blood flow in progressive systemic sclerosis?].Razo-Rodriguez, A. C., Chirino, Y.
I., Sanchez-Gonzalez, D. J., Martinez-Martinez, C.
M., Cruz, C., and Pedraza-Chaverri, J. Garlic powder ameliorates cisplatin-induced nephrotoxicity and oxidative stress.Reinhart, K. M., Coleman, C. I., Teevan, C., Vachhani, P., and White, C. M. Effects of garlic on blood pressure in patients with and without systolic hypertension: a meta-analysis.Ried, K., Frank, O.
R., and Stocks, N. P.
Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial.Russell, J. E. Chinese complementary therapy for stress causing bilateral chemical burns to the feet.Sabitha, P., Adhikari, P. M., Shenoy, S.
M., Kamath, A., John, R., Prabhu, M. V., Mohammed, S., Baliga, S., and Padmaja, U. Efficacy of garlic paste in oral candidiasis.Saleem, S., Ahmad, M., Ahmad, A. S., Yousuf, S., Ansari, M.
A., Khan, M. B., Ishrat, T., and Islam, F. Behavioral and histologic neuroprotection of aqueous garlic extract after reversible focal cerebral ischemia.Salem, S., Salahi, M., Mohseni, M., Ahmadi, H., Mehrsai, A., Jahani, Y., and Pourmand, G.
Major dietary factors and prostate cancer risk: a prospective multicenter case-control study.A. and Abasiyanik, F. M. Does regular garlic intake affect the prevalence of Helicobacter pylori in asymptomatic subjects?Salman, H., Bergman, M., Bessler, H., Punsky, I., and Djaldetti, M.
Effect of a garlic derivative (alliin) on peripheral blood cell immune responses.Sandhu, D. K., Warraich, M. K., and Singh, S. Sensitivity of yeasts isolated from cases of vaginitis to aqueous extracts of garlic.Effect of garlic (Allium sativum) on lipid peroxidation in experimental myocardial infarction in rats.Sarrell, E. M., Cohen, H. A., and Kahan, E.
Naturopathic treatment for ear pain in children.Seuri, M., Taivanen, A., Ruoppi, P., and Tukiainen, H. Three cases of occupational asthma and rhinitis caused by garlic.Shakeel, M., Trinidade, A., McCluney, N., and Clive, B. Complementary and alternative medicine in epistaxis: a point worth considering during the patient's history.Sheela, C.
G. and Augusti, K.
T. Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn.Shu, X.
O., Zheng, W., Potischman, N., Brinton, L. A., Hatch, M.
C., Gao, Y. T., and Fraumeni, J.
F., Jr. A population-based case-control study of dietary factors and endometrial cancer in Shanghai, People's Republic of China.Siegel G.
Long-term effect of garlic in preventing arteriosclerosis - results of two controlled clinical trials.The effects of garlic preparation against human tumour cell proliferation.B., Vinjamury, S. P., Der-Martirosian, C., Kubik, E., Mishra, L.
C., Shepard, N. P., Singh, V. J., Meier, M., and Madhu, S. G.
Ayurvedic and collateral herbal treatments for hyperlipidemia: a systematic review of randomized controlled trials and quasi-experimental designs.Sitprija, S., Plengvidhya, C., Kangkaya, V., Bhuvapanich, S., and Tunkayoon, M. Garlic and diabetes mellitus phase II clinical trial.Smyth, A.
R., Cifelli, P. M., Ortori, C. A., Righetti, K., Lewis, S., Erskine, P., Holland, E.
D., Givskov, M., Williams, P., Camara, M., Barrett, D. A., and Knox, A. Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis--a pilot randomized controlled trial.A., Andrianova, I.
V., Demidova, O. N., Gorchakova, T., and Orekhov, A.
N. Lipid-lowering effects of time-released garlic powder tablets in double-blinded placebo-controlled randomized study.A., Nedosugova, L.
V., Filatova, L. V., Balabolkin, M. I., Gorchakova, T. V., and Orekhov, A.
N. Metabolic effects of time-released garlic powder tablets in type 2 diabetes mellitus: the results of double-blinded placebo-controlled study.A., Prianishnikov, V.
V., Kunnova, L. M., Rabinovich, E. A., and Orekhov, A.
N. [Allicor efficacy in lowering the risk of ischemic heart disease in primary prophylaxis].A., Prianishnikov, V. V., Kunnova, L. M., Rabinovich, E.
A., and Orekhov, A. N.
[Use of allicor to lower the risk of myocardial infarction].A., Prianishnikov, V. V., Kunnova, L.
M., Radinovich, E. A., and Orekhov, A. N. [Reduction of cardiovascular risk in primary prophylaxy of coronary heart disease].A., Martirosyan, D.
M., and Orekhov, A. N.
The effects of time-released garlic powder tablets on multifunctional cardiovascular risk in patients with coronary artery disease.Soffar, S. A.
and Mokhtar, G. M. Evaluation of the antiparasitic effect of aqueous garlic (Allium sativum) extract in hymenolepiasis nana and giardiasis.Preecampisia [sic] is an important complication of pregnancy which can result in morbidity and mortality in mother, fetus and the neonate.Sparnins, V.
L., Barany, G., and Wattenberg, L. W. Effects of organosulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouse.Stabler, S. N., Tejani, A.
M., Huynh, F., and Fowkes, C. Garlic for the prevention of cardiovascular morbidity and mortality in hypertensive patients.Subramanian P, Sundaresan S, and Manivasagam T.
Influence of garlic extract on temporal characteristics of lipid peroxidation products and antioxidants in tumor-bearing rats.Sundaresan S and Subramanian P. Evaluation of chemopreventive potential of garlic extract on N-nitrosodiethylamine-induced hepatocarcinoma in rats.Z., Cai, S.
K., Hou, Y., Luo, Q. S., and Blot, W. J. Dietary determinants of lung-cancer risk: results from a case-control study in Yunnan Province, China.Szybejko, J., Zukowski, A., and Herbec, R.
[Unusual cause of obturation of the small intestine].Takeuchi, S., Matsuzaki, Y., Ikenaga, S., Nishikawa, Y., Kimura, K., Nakano, H., and Sawamura, D. Garlic-induced irritant contact dermatitis mimicking nail psoriasis.Tanaka, S., Haruma, K., Kunihiro, M., Nagata, S., Kitadai, Y., Manabe, N., Sumii, M., Yoshihara, M., Kajiyama, G., and Chayama, K.
Effects of aged garlic extract (AGE) on colorectal adenomas: a double-blinded study.Tanaka, S., Haruma, K., Yoshihara, M., Kajiyama, G., Kira, K., Amagase, H., and Chayama, K. Aged garlic extract has potential suppressive effect on colorectal adenomas in humans.Tanamai, J., Veeramanomai, S., and Indrakosas, N. The efficacy of cholesterol-lowering action and side effects of garlic enteric coated tablets in man.Thabrew, M. I., Samarawickrema, N. A., Chandrasena, L. G., and Jayasekera, S.
Protection by garlic against adriamycin induced alterations in the oxido-reductive status of mouse red blood cells.Thamburan, S., Klaasen, J., Mabusela, W. T., Cannon, J.
F., Folk, W., and Johnson, Q. Tulbaghia alliacea phytotherapy: a potential anti-infective remedy for candidiasis.The garlic-derived organosulfur component ajoene decreases basal cell carcinoma tumor size by inducing apoptosis.Mechanism of antioxidation, inhibiting carcinogenesis and modification of LDL of aged garlic extract.Pharmaceutical Care and Research (Yaoxue Fuwu Yu Yanjiu) (CHINA) 2002;2:122-124.Tsai PB, Harnack LJ, Anderson KE, and et al. Dietary intake of garlic and other Allium vegetables and breast cancer risk in a prospective study of postmenopausal women.Tsai, Y., Cole, L. L., Davis, L.
E., Lockwood, S. J., Simmons, V., and Wild, G. C.
Antiviral properties of garlic: in vitro effects on influenza B, herpes simplex and coxsackie viruses.Tu, H. K., Pan, K. F., Zhang, Y., Li, W. Q., Zhang, L., Ma, J. L., Li, J. Y., and You, W.
C. Manganese superoxide dismutase polymorphism and risk of gastric lesions, and its effects on chemoprevention in a Chinese population.Turner, B., Molgaard, C., and Marckmann, P.
Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomised, double-blind, placebo-controlled trial.Tutakne, M. A., Satyanarayanan, G., Bhardwaj, J. R., and Sethi, I.
C. Sporotrichosis treated with garlic juice.Unnikrishnan, M. C., Soudamini, K. K., and Kuttan, R.
Chemoprotection of garlic extract toward cyclophosphamide toxicity in mice.Unsal, A., Eroglu, M., Avci, A., Cimentepe, E., Guven, C., Derya, Balbay M., and Durak, I.Vaes, L. P. and Chyka, P. A.
Interactions of warfarin with garlic, ginger, ginkgo, or ginseng: nature of the evidence.van der Walt, A., Lopata, A. L., Nieuwenhuizen, N.
E., and Jeebhay, M. F.
Work-related allergy and asthma in spice mill workers - The impact of processing dried spices on IgE reactivity patterns.van Doorn, M. B., Espirito Santo, S.
M., Meijer, P., Kamerling, I. M., Schoemaker, R. C., Dirsch, V., Vollmar, A., Haffner, T., Gebhardt, R., Cohen, A.
F., Princen, H. M., and Burggraaf, J.Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects.van Ketel, W. G.
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[Clinical evaluation and tolerability of a drug with garlic and hawthorn].Wang, B. H., Zuzel, K. A., Rahman, K., and Billington, D.
Protective effects of aged garlic extract against bromobenzene toxicity to precision cut rat liver slices.Wang, E. J., Li, Y., Lin, M., Chen, L., Stein, A. P., Reuhl, K.
R., and Yang, C. S.
Protective effects of garlic and related organosulfur compounds on acetaminophen-induced hepatotoxicity in mice.Wang, Y., Zhang, L., Moslehi, R., Ma, J., Pan, K., Zhou, T., Liu, W., Brown, L. M., Hu, Y., Pee, D., Gail, M.
H., and You, W. Long-term garlic or micronutrient supplementation, but not anti-Helicobacter pylori therapy, increases serum folate or glutathione without affecting serum vitamin B-12 or homocysteine in a rural Chinese population.Wang, Z. Y., Boice, J. D., Jr., Wei, L.
X., Beebe, G. W., Zha, Y. R., Kaplan, M. M., Tao, Z. F., Maxon, H. R., III, Zhang, S.
Z., Schneider, A.Thyroid nodularity and chromosome aberrations among women in areas of high background radiation in China.Wargovich, M. J. Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethylhydrazine-induced colon cancer.Wargovich, M. J., Uda, N., Woods, C., Velasco, M., and McKee, K. Allium vegetables: their role in the prevention of cancer.Aged garlic extract improves endothelial function in men with coronary artery disease.Wongmekiat, O. and Thamprasert, K.
Investigating the protective effects of aged garlic extract on cyclosporin-induced nephrotoxicity in rats.Xiao, D., Pinto, J. T., Soh, J.
W., Deguchi, A., Gundersen, G. G., Palazzo, A. F., Yoon, J. T., Shirin, H., and Weinstein, I.Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation.Xie, W. and Du, L. Diabetes is an inflammatory disease: evidence from traditional Chinese medicines.Yoshikawa, K., Hadame, K., Saitoh, K., and Hijikata, T.
Patch tests with common vegetables in hand dermatitis patients.Effect of aged garlic extract against methotrexate-induced damage to the small intestine in rats.Zamani, A., Vahidinia, A., and Ghannad, M. S.
The effect of garlic consumption on Th1/Th2 cytokines in phytohemagglutinin (PHA) activated rat spleen lymphocytes.Zeybek, A., Cikler, E., Saglam, B., Ercan, F., Cetinel, S., and Sener, G. Aqueous garlic extract inhibits protamine sulfate-induced bladder damage.Zhang, L., Gail, M. H., Wang, Y. Q., Brown, L. M., Pan, K. F., Ma, J.
L., Amagase, H., You, W. C., and Moslehi, R.
A randomized factorial study of the effects of long-term garlic and micronutrient supplementation and of 2-wk antibiotic treatment for Helicobacter pylori infection on serum cholesterol and lipoproteins.Z., and Li, B. Allitridum mimics effect of ischemic preconditioning by activation of protein kinase C.
Acta Pharmacol.Sin.A randomized trial of the effects of garlic oil upon coronary heart disease risk factors in trained male runners.Zhang, Z. D., Li, Y., and Jiao, Z. K.
[Effect of local application of allicinvia gastroscopy on cell proliferation and apoptosis of progressive gastric carcinoma].Zheng, W., Blot, W. J., Shu, X. O., Diamond, E. L., Gao, Y.
T., Ji, B. T., and Fraumeni, J. F., Jr.
A population-based case-control study of cancers of the nasal cavity and paranasal sinuses in Shanghai.Zheng, W., Blot, W. J., Shu, X. O., Gao, Y.
T., Ji, B. T., Ziegler, R.
G., and Fraumeni, J. F., Jr.Reduction in elevated blood lipids in hospitalised patients by a standardised garlic preparation.Ackermann RT, Mulrow CD, Ramirez G, et al.
Garlic shows promise for improving some cardiovascular risk factors.Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men.Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men.Effect of topical garlic on wound healing and scarring: A clinical trial.Ali M, Bordia T, Mustafa T. Effect of raw versus boiled aqueous extract of garlic and onion on platelet aggregation.Ali M, Thomson M, Afzal M. Garlic and onions: their effect on eicosanoid metabolism and its clinical relevance.The Effect of Garlic Tablets on the Endometriosis-Related Pains: A Randomized Placebo-Controlled Clinical Trial.Hussain, S.
P., Jannu, L. N., and Rao, A. R. Chemopreventive action of garlic on methylcholanthrene-induced carcinogenesis in the uterine cervix of mice.Huynh F, Fowkes C, and Tejani A.
Garlic for the prevention of cardiovascular morbidity and mortality in hypertensive patients.Aged garlic extract and its constituents inhibit Cu2+ -induced oxidative modification of low density lipoprotein.Ishikawa, H., Saeki, T., Otani, T., Suzuki, T., Shimozuma, K., Nishino, H., Fukuda, S., and Morimoto, K. Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer.Jabbari, A., Argani, H., Ghorbanihaghjo, A., and Mahdavi, R. Comparison between swallowing and chewing of garlic on levels of serum lipids, cyclosporine, creatinine and lipid peroxidation in Renal Transplant Recipients.Jain, R.
C. Effect of garlic on serum lipids, coagulability and fibrinolytic activity of blood.Gupta, N. and Porter, T.
D. Garlic and garlic-derived compounds inhibit human squalene monooxygenase.Hajheydari, Z., Jamshidi, M., Akbari, J., and Mohammadpour, R.
Combination of topical garlic gel and betamethasone valerate cream in the treatment of localized alopecia areata: a double-blind randomized controlled study.Hansson LE, Nyren O, and Bergstrom R. Diet and risk of gastric cancer: a population-based case-control study in Sweden.Harenberg, J., Giese, C., and Zimmermann, R. Effect of dried garlic on blood coagulation, fibrinolysis, platelet aggregation and serum cholesterol levels in patients with hyperlipoproteinemia.Hasani-Ranjbar, S., Larijani, B., and Abdollahi, M.
A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases.Hasani-Ranjbar, S., Nayebi, N., Moradi, L., Mehri, A., Larijani, B., and Abdollahi, M. The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review.Hassan, Z. M., Yaraee, R., Zare, N., Ghazanfari, T., Sarraf Nejad, A. H., and Nazori, B.
Immunomodulatory affect of R10 fraction of garlic extract on natural killer activity.Helen, A., Krishnakumar, K., Vijayammal, P. L., and Augusti, K.
T. A comparative study of antioxidants S-allyl cysteine sulfoxide and vitamin E on the damages induced by nicotine in rats.Henning, S.
M., Zhang, Y., Seeram, N. P., Lee, R. P., Wang, P., Bowerman, S., and Heber, D. Antioxidant capacity and phytochemical content of herbs and spices in dry, fresh and blended herb paste form.Higashikawa, F., Noda, M., Awaya, T., Ushijima, M., and Sugiyama, M. Reduction of serum lipids by the intake of the extract of garlic fermented with Monascus pilosus: a randomized, double-blind, placebo-controlled clinical trial.Hikino, H., Tohkin, M., Kiso, Y., Namiki, T., Nishimura, S., and Takeyama, K. Antihepatotoxic actions of Allium sativum bulbs.Hiltunen, R., Josling, P.
D., and James, M. H. Preventing airborne infection with an intranasal cellulose powder formulation (Nasaleze travel).Hirsch, K., Danilenko, M., Giat, J., Miron, T., Rabinkov, A., Wilchek, M., Mirelman, D., Levy, J., and Sharoni, Y.Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation.Hsu, C. C., Huang, C.
N., Hung, Y. C., and Yin, M. C. Five cysteine-containing compounds have antioxidative activity in Balb/cA mice.Hu, J., Nyren, O., Wolk, A., Bergstrom, R., Yuen, J., Adami, H. O., Guo, L., Li, H., Huang, G., Xu, X., and .Hughes BG, Murray BK, North JA, and et al. Antiviral constituents from Allium sativum.Hughes, T.
M., Varma, S., and Stone, N. M.
Occupational contact dermatitis from a garlic and herb mixture.Hurley, M. N., Forrester, D. L., and Smyth, A. R. Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis.Feldberg, R. S., Chang, S.
C., Kotik, A. N., Nadler, M., Neuwirth, Z., Sundstrom, D. C., and Thompson, N.
H. In vitro mechanism of inhibition of bacterial cell growth by allicin.Friedman, T., Shalom, A., and Westreich, M.
Self-inflicted garlic burns: our experience and literature review.Gaddoni G, Selvi M, Resta F, and et al. Allergic contact dermatitis to garlic in a cook.Gail M, You WC, Chang YS, and et al. Factorial trial of three interventions to reduce the progression of precancerous gastric lesions in Shandong, China: Design issues and initial data.Gail, M.
H. and You, W. C.
A factorial trial including garlic supplements assesses effect in reducing precancerous gastric lesions.Galduroz, J. C., Antunes, H. K., and Santos, R. F. Gender- and age-related variations in blood viscosity in normal volunteers: a study of the effects of extract of Allium sativum and Ginkgo biloba.Gallwitz, H., Bonse, S., Martinez-Cruz, A., Schlichting, I., Schumacher, K., and Krauth-Siegel, R. L.
Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies.Gamboa-Leon, M. R., Aranda-Gonzalez, I., Mut-Martin, M., Garcia-Miss, M.
R., and Dumonteil, E. In vivo and in vitro control of Leishmania mexicana due to garlic-induced NO production.Gao YT, McLaughlin JK, and Gridley G. Risk factors for esophageal cancer in Shanghai, China.Gao, C. M., Takezaki, T., Ding, J.
H., Li, M. S., and Tajima, K.
Protective effect of allium vegetables against both esophageal and stomach cancer: a simultaneous case-referent study of a high-epidemic area in Jiangsu Province, China.Effect of garlic supplementation on plasma lipids in hypercholesterolemic men and women.Gebhardt R, Beck H, and Wagner K. Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells.Germain, E., Auger, J., Ginies, C., Siess, M.
H., and Teyssier, C. In vivo metabolism of diallyl disulphide in the rat: identification of two new metabolites.Ghannoum, M. A. Inhibition of Candida adhesion to buccal epithelial cells by an aqueous extract of Allium sativum (garlic).Studies on the anticandidal mode of action of Allium sativum (garlic).Ghazanfari, T., Hassan, Z.
M., and Khamesipour, A. Enhancement of peritoneal macrophage phagocytic activity against Leishmania major by garlic (Allium sativum) treatment.Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, and Willett WC.Intake of fat, meat, and fiber in relation to risk of colon cancer in men.Groppo, F.
C., Ramacciato, J. C., Motta, R. H., Ferraresi, P.
M., and Sartoratto, A. Antimicrobial activity of garlic against oral streptococci.Groppo, F. C., Ramacciato, J. C., Simoes, R.
P., Florio, F. M., and Sartoratto, A. Antimicrobial activity of garlic, tea tree oil, and chlorhexidine against oral microorganisms.Guo, N. L., Lu, D. P., Woods, G. L., Reed, E., Zhou, G.
Z., Zhang, L. B., and Waldman, R. H.
Demonstration of the anti-viral activity of garlic extract against human cytomegalovirus in vitro.Guo, Y., Zhang, K., Wang, Q., Li, Z., Yin, Y., Xu, Q., Duan, W., and Li, C. Neuroprotective effects of diallyl trisulfide in SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis.Dorant, E., van den Brandt, P. A., Goldbohm, R. A., and Sturmans, F.
Consumption of onions and a reduced risk of stomach carcinoma.A., Breckler, L., Hale, J., Lehmann, H., Franklin, P., Lyons, G., Ching, S. Y., Mori, T.
A., Barden, A., and Prescott, S. L. Supplementation with vitamins C, E, beta-carotene and selenium has no effect on anti-oxidant status and immune responses in allergic adults: a randomized controlled trial.Durak, I., Kavutcu, M., Aytac, B., Avci, A., Devrim, E., Ozbek, H., and Ozturk, H.
S. Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol.Dwivedi, C., John, L. M., Schmidt, D. S., and Engineer, F.
N. Effects of oil-soluble organosulfur compounds from garlic on doxorubicin-induced lipid peroxidation.Egen-Schwind C, Eckard R, Jekat FW, and et al. Pharmacokinetics of vinyldithiins, transformation products of allicin.Eguchi, A., Murakami, A., and Ohigashi, H. Novel bioassay system for evaluating anti-oxidative activities of food items: use of basolateral media from differentiated Caco-2 cells.El Beshbishy, H. A. Aqueous garlic extract attenuates hepatitis and oxidative stress induced by galactosamine/lipoploysaccharide in rats.Eming, S.
A., Piontek, J. O., Hunzelmann, N., Rasokat, H., and Scharffetter-Kachanek, K.
Severe toxic contact dermatitis caused by garlic.Fani, M. M., Kohanteb, J., and Dayaghi, M. Inhibitory activity of garlic (Allium sativum) extract on multidrug-resistant Streptococcus mutans.Baluchnejadmojarad, T., Roghani, M., Homayounfar, H., and Hosseini, M.
Beneficial effect of aqueous garlic extract on the vascular reactivity of streptozotocin-diabetic rats.Banerjee, S. K., Dinda, A. K., Manchanda, S. C., and Maulik, S. K. Chronic garlic administration protects rat heart against oxidative stress induced by ischemic reperfusion injury.Effects of garlic oil on platelet aggregation, serum lipids and blood pressure in humans.Belman, S.
Onion and garlic oils inhibit tumor promotion.A., and Orekhov, A. N. [Study of the antioxidant drug "Karinat" in patients with chronic atrophic gastritis].A., Krzhivitskii, P.
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Effect of garlic on normal blood cholesterol level.Bhuvaneswari, V., Abraham, S. K., and Nagini, S. Combinatorial antigenotoxic and anticarcinogenic effects of tomato and garlic through modulation of xenobiotic-metabolizing enzymes during hamster buccal pouch carcinogenesis.Bimmermann A, Weingart K, and Schwartzkopff W.
Allium sativum: Studie zur Wirksamkeit bei Hyperlipoproteinamie.Bleumink, E., Doeglas, H. M., Klokke, A.
H., and Nater, J. P. Allergic contact dermatitis to garlic.Effect of garlic on blood lipids in patients with coronary heart disease.Bordia, A.
K., Joshi, H. K., Sanadhya, Y.
K., and Bhu, N. Effect of essential oil of garlic on serum fibrinolytic activity in patients with coronary artery disease.Bordia, A., Bansal, H. C., Arora, S.
K., and Singh, S. V. Effect of the essential oils of garlic and onion on alimentary hyperlipemia.Bordia, A., Verma, S.
K., and Srivastava, K. C. Effect of garlic on platelet aggregation in humans: a study in healthy subjects and patients with coronary artery disease.Bordia, T., Mohammed, N., Thomson, M., and Ali, M.
An evaluation of garlic and onion as antithrombotic agents.B., and Eling, T. E.
Diallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells.Bradley R, Endres J, Hockenberry D, and et al. Investigation of garlic-induced apoptosis in breast cancer cell lines [poster presentation].International Scientific Conference on Complementary, Alternative and Integrative Medicine Research, Boston, MA, 2002.Brosche, T., Platt, D., and Dorner, H. The effect of a garlic preparation on the composition of plasma lipoproteins and erythrocyte membranes in geriatric subjects.Budoff, M.
J., Takasu, J., Flores, F. R., Niihara, Y., Lu, B., Lau, B.
H., Rosen, R. T., and Amagase, H. Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study.Buiatti, E., Palli, D., Decarli, A., Amadori, D., Avellini, C., Bianchi, S., Biserni, R., Cipriani, F., Cocco, P., Giacosa, A., and .Byrne, D.
J., Neil, H. A., Vallance, D.
T., and Winder, A. F. A pilot study of garlic consumption shows no significant effect on markers of oxidation or sub-fraction composition of low-density lipoprotein including lipoprotein(a) after allowance for non-compliance and the placebo effect.Canduela, V., Mongil, I., Carrascosa, M., Docio, S., and Cagigas, P. Garlic: always good for the health?Caporaso, N., Smith, S.
M., and Eng, R. H.
Antifungal activity in human urine and serum after ingestion of garlic (Allium sativum).Challier, B., Perarnau, J. M., and Viel, J.
F. Garlic, onion and cereal fibre as protective factors for breast cancer: a French case-control study.Chauhan, N.
B. and Sandoval, J.
Amelioration of early cognitive deficits by aged garlic extract in Alzheimer's transgenic mice.Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer's transgenic model Tg2576.Chu, Q., Lee, D. T., Tsao, S.
W., Wang, X., and Wong, Y. C. S-allylcysteine, a water-soluble garlic derivative, suppresses the growth of a human androgen-independent prostate cancer xenograft, CWR22R, under in vivo conditions.Cohain, J. S.
Long-term symptomatic group B streptococcal vulvovaginitis: eight cases resolved with freshly cut garlic.Das, I., Khan, N. S., and Sooranna, S. R.
Potent activation of nitric oxide synthase by garlic: a basis for its therapeutic applications.Das, I., Patel, S., and Sooranna, S. R. Effects of aspirin and garlic on cyclooxygenase-induced chemiluminescence in human term placenta.In vitro synergism of concentrated allium sativum extract and amphotericin B against cryptococcus neoformans.Davis, L. E., Shen, J.
K., and Cai, Y. Antifungal activity in human cerebrospinal fluid and plasma after intravenous administration of Allium sativum.Davis, S. R., Perrie, R., and Apitz-Castro, R. The in vitro susceptibility of Scedosporium prolificans to ajoene, allitridium and a raw extract of garlic (Allium sativum).de Rooij, B. M., Boogaard, P. J., Rijksen, D.
A., Commandeur, J. N., and Vermeulen, N.
P. Urinary excretion of N-acetyl-S-allyl-L-cysteine upon garlic consumption by human volunteers.Delaha, E. C. and Garagusi, V.
F. Inhibition of mycobacteria by garlic extract (Allium sativum).Demirkaya, E., Avci, A., Kesik, V., Karslioglu, Y., Oztas, E., Kismet, E., Gokcay, E., Durak, I., and Koseoglu, V.
Cardioprotective roles of aged garlic extract, grape seed proanthocyanidin, and hazelnut on doxorubicin-induced cardiotoxicity.Deshpande, R. G., Khan, M. B., Bhat, D.
A., and Navalkar, R. G. Inhibition of Mycobacterium avium complex isolates from AIDS patients by garlic (Allium sativum).Dhawan, V.
and Jain, S. Effect of garlic supplementation on oxidized low density lipoproteins and lipid peroxidation in patients of essential hypertension.Dillon, S.
A., Lowe, G. M., Billington, D., and Rahman, K.
Dietary supplementation with aged garlic extract reduces plasma and urine concentrations of 8-iso-prostaglandin F(2 alpha) in smoking and nonsmoking men and women.Dirsch VM, Kiemer AK, Wagner H, and et al. Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase.Dirsch, V. M., Gerbes, A. L., and Vollmar, A.
M. Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB.Dixit, V. P.
and Joshi, S. Effects of chronic administration of garlic (Allium sativum Linn) on testicular function.Abbruzzese, M.
R., Delaha, E. C., and Garagusi, V.
F. Absence of antimycobacterial synergism between garlic extract and antituberculosis drugs.[Two cases of eosinophilic gastroenteritis whose causative allergens are usefully diagnosed by patch test].Adetumbi, M., Javor, G. T., and Lau, B. H. Allium sativum (garlic) inhibits lipid synthesis by Candida albicans.Ahmad, M. S., Pischetsrieder, M., and Ahmed, N.
Aged garlic extract and S-allyl cysteine prevent formation of advanced glycation endproducts.Ahmadi, N., Tsimikas, S., Hajsadeghi, F., Saeed, A., Nabavi, V., Bevinal, M. A., Kadakia, J., Flores, F., Ebrahimi, R., and Budoff, M.
J.Relation of oxidative biomarkers, vascular dysfunction, and progression of coronary artery calcium.Ali, M. and Thomson, M. Consumption of a garlic clove a day could be beneficial in preventing thrombosis.Ali, M. Mechanism by which garlic (Allium sativum) inhibits cyclooxygenase activity.Effect of raw versus boiled garlic extract on the synthesis of prostanoids.Ambati, S., Yang, J.
Y., Rayalam, S., Park, H. J., Della-Fera, M.
A., and Baile, C. A.
Ajoene exerts potent effects in 3T3-L1 adipocytes by inhibiting adipogenesis and inducing apoptosis.Andrianova, I. V., Fomchenkov, I. V., and Orekhov, A.
N. [Hypotensive effect of long-acting garlic tablets allicor (a double-blind placebo-controlled trial)].A., Karabasova, IaA, Liutova, L. I., Povorinskaia, T. E., and Orekhov, A. N. [Use of allikor for the normalization of fibrinolysis and hemostasis in patients with chronic cerebrovascular diseases].[Effect of long-acting garlic tablets "allicor" on the incidence of acute respiratory viral infections in children].Anim-Nyame, N., Sooranna, S.
R., Johnson, M. R., Gamble, J., and Steer, P. J.
Garlic supplementation increases peripheral blood flow: a role for interleukin-6?Anthony, J. P., Fyfe, L., and Smith, H. Plant active components - a resource for antiparasitic agents?Apitz-Castro, R., Escalante, J., Vargas, R., and Jain, M.
K. Ajoene, the antiplatelet principle of garlic, synergistically potentiates the antiaggregatory action of prostacyclin, forskolin, indomethacin and dypiridamole on human platelets.Ashraf, M. Z., Hussain, M. E., and Fahim, M. Endothelium mediated vasorelaxant response of garlic in isolated rat aorta: role of nitric oxide.Ashraf, R., Aamir, K., Shaikh, A. R., and Ahmed, T.
Effects of garlic on dyslipidemia in patients with type 2 diabetes mellitus.Augusti, K. T.
and Sheela, C. G.
Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats.Effects of garlic consumption on plasma and erythrocyte antioxidant parameters in elderly subjects.Ayala-Zavala, J. F., Gonzalez-Aguilar, G. A., and Toro-Sanchez, L. Enhancing safety and aroma appealing of fresh-cut fruits and vegetables using the antimicrobial and aromatic power of essential oils.Bagga, S., Thomas, B. S., and Bhat, M. Garlic burn as self-inflicted mucosal injury--a case report and review of the literature.B., Shabestari, S.
B., Tanik, A., and Pahlevan, R. Comparison of therapeutic effect of aqueous extract of garlic and nystatin mouthwash in denture stomatitis.Bakri, I. M.
and Douglas, C. W. Inhibitory effect of garlic extract on oral bacteria.Balasenthil, S., Ramachandran, C. R., and Nagini, S. Prevention of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis by garlic.Balasenthil, S., Rao, K. S., and Nagini, S.
Altered cytokeratin expression during chemoprevention of experimental hamster buccal pouch carcinogenesis by garlic.Balasenthil, S., Rao, K. S., and Nagini, S.
Retinoic acid receptor-beta mRNA expression during chemoprevention of hamster cheek pouch carcinogenesis by garlic.Baluchnejadmojarad, T. and Roghani, M. Endothelium-dependent and -independent effect of aqueous extract of garlic on vascular reactivity on diabetic rats.Anibarro B, Fontela JL, De La Hoz F. Occupational asthma induced by garlic dust.Asgharpour M, Khavandegar A, Balaei P, et al. Efficacy of Oral Administration of Allium sativum Powder "Garlic Extract" on Lipid Profile, Inflammation, and Cardiovascular Indices among Hemodialysis Patients.Effects of Allium sativum (garlic) on systolic and diastolic blood pressure in patients with essential hypertension.Effects of garlic supplementation on oxidative stress and antioxidative capacity biomarkers: A systematic review and meta-analysis of randomized controlled trials.Aydin A, Ersoz G, Tekesin O, et al. Garlic oil and Helicobacter pylori infection.Bahadoran P, Rokni FK, Fahami F.
Investigating the therapeutic effect of vaginal cream containing garlic and thyme compared to clotrimazole cream for the treatment of mycotic vaginitis.Berthold HK, Sudhop T, von Bergmann K. Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism.Garlic (Allium sativum L.): adverse effects and drug interactions in humans.Protective effect of chronic garlic intake on elastic properties of aorta in the elderly.Calvet X, Carod C, Gene E. Re: Peppers at treatment for Helicobacter pylori infection.Effect of cooking on garlic (Allium sativum l.) Antiplatelet activity and thiosulfinates content.Effects of garlic on lipid metabolism in rats fed cholesterol or lard.Chiavarini M, Minelli L, Fabiani R. Garlic consumption and colorectal cancer risk in man: a systematic review and meta-analysis.Choudhary PR, Jani RD, Sharma MS. Effect of raw crushed garlic (Allium sativum L.) on components of metabolic syndrome.The effect of fried versus raw garlic on fibrinolytic activity in man.Dehghani F, Merat A, Panjehshahin MR, Handjani F. Healing effect of garlic extract on warts and corns.The effect of a garlic supplement on the pro-inflammatory adipocytokines, resistin and tumor necrosis factor-alpha, and on pain severity, in overweight or obese women with knee osteoarthritis.Desai G, Schelske-Santos M, Nazario CM, et al.
Onion and garlic intake and breast cancer, a case-control study in Puerto Rico.Dev T, Bharti P, Patel U, Bhari N. Chronic paronychia and nail dystrophy: an atypical presentation of allergic contact dermatitis to garlic.Dhamija P, Malhotra S, Pandhi P.
Effect of oral administration of crude aqueous extract of garlic on pharmacokinetic parameters of isoniazid and rifampicin in rabbits.Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase.A prospective cohort study on Allium vegetable consumption, garlic supplement use, and the risk of lung carcinoma in The Netherlands.Allium vegetable consumption, garlic supplement intake, and female breast carcinoma incidence.A prospective cohort study on the relationship between onion and leek consumption, garlic supplement use and the risk of colorectal carcinoma in The Netherlands.An unusual case of HIV virologic failure during treatment with boosted atazanavir.Ernst E. Is garlic an effective treatment for Helicobacter pylori infection?Fleischauer AT, Arab L. Garlic and cancer: a critical review of the epidemiologic literature.Effect of ingestion of raw garlic on serum cholesterol level, clotting time and fibrinolytic activity in normal subjects.Gallicano K, Foster B, Choudhri S. Effect of short-term administration of garlic supplements on single-dose ritonavir pharmacokinetics in healthy volunteers.Gandomkar H, Mahmoodzadeh H, Tavakoli H, Fazeli M, Rezaei J.
Garlic-induced esophageal perforation: A case series.The effect of a garlic preparation on plasma lipid levels in moderately hypercholesterolemic adults.Gardner CD, Lawson LD, Block E, et al. Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial.Gebhardt R and Beck H.
Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures.Gebhardt R, Beck H. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures.Ghorai M, Mandal SC, Pal M, et al.
A comparative study on hypocholesterolaemic effect of allicin, whole germinated seeds of bengal gram and guggulipid of gum gugglu.Graham DY, Anderson SY, Lang T. Garlic or jalapeno peppers for treatment of Helicobacter pylori infection.Relationship between consumption of raw garlic and handgrip strength in a large-scale adult population.Gurley BJ, Gardner SF, Hubbard MA, et al.
Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans.AAPS Ann Mtg & Expo Indianapolis, IN: 2000; Oct 29 - Nov 2:presentation #3460.Calabash chalk may pose health risk for pregnant and breastfeeding women.Horie T, Awazu S, Itakura Y, Fuwa T. Alleviation by garlic of antitumor drug-induced damage to the intestine.Protective effect of aged garlic extract on the small intestinal damage of rats induced by methotrexate administration.Garlic intake lowers fasting blood glucose: meta-analysis of randomized controlled trials.Hsing AW, Chokkalingam AP, Gao YT, et al. Allium vegetables and risk of prostate cancer: a population-based study.Aged garlic extract reduces left ventricular myocardial mass in patients with diabetes: A prospective randomized controlled double-blind study.Garlic compounds protect vascular endothelial cells from oxidized low density lipoprotein-induced injury.Imai J, Ide N, Nagae S, et al. Antioxidant and radical scavenging effects of aged garlic extract and its constituents.Efficacy of cancer prevention by high-selenium garlic is primarily dependent on the action of selenium.Isaacsohn JL, Moser M, Stein EA, et al.
Garlic powder and plasma lipids and lipoproteins, a multicenter, randomized, placebo-controlled trial.Effect of Garlic (Allium sativum) Supplementation on Premenstrual Disorders: A Randomized, Double-Blind, Placebo-Controlled Trial.Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review.Effect of a combined supplementation of fish oil (MEGA-3) with garlic pearls on the serum lipid profile, blood pressure and body mass index of hypercholesterolemic subjects.Kanerva L, Estlander T, Jolanki R.
Occupational allergic contact dermatitis from spices.Kenzelmann R, Kade F. Limitation of the deterioration of lipid parameters by a standardized garlic-ginkgo combination product.Key TJ, Silcocks PB, Davey GK, et al.
A case-control study of diet and prostate cancer.Effects of garlic extract on lipid profile in patients with coronary artery disease: A systematic review and meta-analysis of randomised clinical trials.Effects of garlic coated tablets in peripheral arterial occlusive disease.Kim H, Keum N, Giovannucci EL, Fuchs CS, Bao Y. Garlic intake and gastric cancer risk: results from two large prospective US cohort studies.Effect of garlic intake on inflammatory mediators: a systematic review and meta-analysis of randomised controlled trials.The potential application of Allium sativum (garlic) for the treatment of bladder cancer.Lau BS, Lam F, Wang-Cheng R. Effect of an odor-modified garlic preparation on blood lipids.Le Marchand L, Hankin JH, Wilkens LR, et al.
Dietary fiber and colorectal cancer risk.Ledezma E, DeSousa L, Jorquera A, et al. Efficacy of ajoene, an organosulphur derived from garlic, in the short-term therapy of tinea pedis.Ledezma E, Marcano K, Jorquera A.
Efficacy of ajoene in the treatment of tinea pedis: A double-blind and comparative study with terbinafine.Contact dermatitis due to topical treatment with garlic in Hong Kong.Effects of a dried garlic preparation on fibrinolysis and platelet aggregation in healthy subjects.Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial.Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. .
Too Much Garlic: Side Effects, How Much to Eat, and More
One of the most serious side effects of eating too much garlic is an increased risk of bleeding, especially if you’re taking blood thinners or undergoing surgery.The possible cause was a dietary supplement the person had been taking, which contained fish oil and 10 mg of garlic concentrate, both of which affect blood clot formation ( 4 ).Like onions, leeks, and asparagus, garlic is high in fructans, a type of carb that may cause bloating, gas, and stomach pain in some people ( 7 ).GERD is a common condition that occurs when stomach acid flows back up into your esophagus, causing symptoms like heartburn and nausea ( 9 ).Garlic may decrease lower esophageal sphincter (LES) tone, which is the ability of the muscles at the bottom of your esophagus to close and prevent acid from entering.If you find that eating a lot of garlic doesn’t cause symptoms, it’s likely unnecessary to limit your intake ( 11 ). .
Secret Side Effects of Eating Garlic, Says Science — Eat This Not That
And now in the modern-day, we love eating garlic for a number of reasons—especially for the flavors it adds to our favorite pasta recipe.These carbs can also be found in foods like wheat, rye, onions, asparagus, grapefruit, watermelon, black beans, and cashews.According to Current Gastroenterology Reports, a FODMAP diet may be helpful for those with a possible fructan intolerance, although more research still needs to be done to determine the effectiveness of this.Our bodies have a lower esophageal sphincter (LES), which is a group of muscles that prevents stomach acid from traveling back up to the esophagus.According to Primary Care, garlic can weaken the "tone" of these LES muscles and cause more heartburn, especially for those with GERD or related struggles.Another study from Clinical Nutrition found that aged garlic extract can have a positive result on immunity as well.After the trial period, it was found that the group taking the extract reported much less severe cold/flu symptoms, as well as less time actually being sick.Garlic may be a helpful anti-fungal agent, but it is recommended as an addition to other types of anti-fungal medicine and shouldn't necessarily be used on its own until more research has been done.According to the Journal of Nutrition, aged garlic extract has been known to lower our chances of cognitive decline while helping to improve our memory and retention.These polysulfides help to regulate what is known as the "redox signaling pathways" in our body, which are the ways in which our cells get important messages about things that need repair or protection. .
Health Effects of Garlic
A more recent meta-analysis10 of placebo-controlled trials using standardized dried garlic powder showed significant reductions in total cholesterol levels (19.2 mg per dL [0.50 mmol per L]), low-density lipoprotein cholesterol levels (6.7 mg per dL [0.20 mmol per L]) and triglyceride levels (21.1 mg per dL [0.24 mmol per L]) at eight to 12 weeks; these reductions were not sustained at six months of treatment. .
Garlic: Proven health benefits and uses
According to experts at Kew Gardens, England’s royal botanical center of excellence, the people of ancient India valued the therapeutic properties of garlic and also thought it to be an aphrodisiac.The original Olympic athletes in Ancient Greece were given garlic – possibly the earliest example of “performance enhancing” agents used in sports.A study published in the journal Food and Chemical Toxicology warned that short-term heating reduces the anti-inflammatory effects of fresh raw garlic extracts.Co-author, Ray Swapan, Ph.D., said “This research highlights the great promise of plant-originated compounds as natural medicine for controlling the malignant growth of human brain tumor cells.Women whose diets were rich in allium vegetables had lower levels of osteoarthritis , a team at King’s College London and the University of East Anglia, both in England, reported in the journal BMC Musculoskeletal Disorders.The study authors said their findings not only highlighted the possible impact of diet on osteoarthritis outcomes but also demonstrated the potential for using compounds that exist in garlic to develop treatments for the condition.The long-term study, involving more than 1,000 healthy female twins, found that those whose dietary habits included plenty of fruit and vegetables, “particularly alliums such as garlic,” had fewer signs of early osteoarthritis in the hip joint.Diallyl sulfide, a compound in garlic, was 100 times more effective than two popular antibiotics in fighting the Campylobacter bacterium, according to a study published in the Journal of Antimicrobial Chemotherapy.Senior author, Dr. Xiaonan Lu, from Washington State University, said, “This work is very exciting to me because it shows that this compound has the potential to reduce disease-causing bacteria in the environment and in our food supply.”.Because of this, the scientists decided to focus on diallyl trisulfide, a garlic oil component, as a safer way to deliver the benefits of hydrogen sulfide to the heart.In another study, published in the Journal of Agricultural and Food Chemistry, scientists found that garlic oil may help protect diabetes patients from cardiomyopathy.The study authors wrote, “In conclusion, garlic oil possesses significant potential for protecting hearts from diabetes-induced cardiomyopathy.”.Doctors at the Department of Urology, China-Japan Friendship Hospital, Beijing, China, carried out a study evaluating the relationship between Allium vegetable consumption and prostate cancer risk.Scientists at the Institute of Toxicology, School of Public Health, Shandong University, China, wanted to determine whether diallyl disulfide (DADS), a garlic-derived organosulfur compound, might have protective effects against ethanol-induced oxidative stress.Scientists at the Division of Epidemiology, Norwegian Institute of Public Health, studied what impact foods might have on antimicrobial infections and preterm delivery risk.Ronny Myhre and colleagues concentrated on the effects of Alliums and dried fruits, because a literature search had identified these two foods as showing the greatest promise for reducing preterm delivery risk.The team investigated the intake of dried fruit and Alliums among 18,888 women in the Norwegian Mother and Child Cohort, of whom 5 percent (950) underwent spontaneous PTD (preterm delivery).The study authors concluded, “Intake of food with antimicrobial and prebiotic compounds may be of importance to reduce the risk of spontaneous PTD. .
6 Garlic Benefits To Boost Your Health – Cleveland Clinic
Dietitian Laura Jeffers, MEd, RD, LD, offers six surprising ways that this herb-like vegetable boosts your health.“Garlic gets its pungent smell from an organic sulfur compound called allicin,” Jeffers says.According to one study involving 41,000 women between the ages of 55 and 69, those who routinely ate garlic, fruits and vegetables had a 35% lower colon cancer risk.Researchers believe red blood cells turn the sulfur in garlic into hydrogen sulfide gas.Before putting your blood pressure medication away, though, consult your doctor to see if adding more garlic to your diet could be beneficial for you.Those same antibacterial properties in fresh garlic can kill the bacteria that lead to food poisoning, including salmonella and E.coli.The enzymes from the allicin need a few minutes to start working, so let it sit after you mince, crush or chop it.Higher temperatures kill the allicin, so add garlic to your recipes when you’re almost done cooking.”.On rare occasions, garlic supplements can cause headaches, fatigue, appetite loss, muscle aches, dizziness and allergic reactions like asthma attacks or skin rashes.“You may also get a stinging feeling on the skin if you handle significant amounts of fresh and dried garlic,” says Jeffers.Overdoing it can cause discomfort, including upset stomach, bloating, diarrhea, body odor and bad breath. .
Effects of Too Much Garlic on the Body
According to National Center for Complementary and Integrated Health (NCCIH), there are limited studies on garlic.When consumed in food, it is not very likely you will come close to hitting an unsafe upper limit of garlic.Though this may benefit the heart and circulation, the NCCIH and the Mayo Clinic warn that it can pose a risk of bleeding for people who use anticoagulants or blood thinners such as warfarin.The NCCIH suggests avoiding garlic supplements prior to surgery as well and points out that garlic supplements may interfere with the effectiveness of certain medications, such as saquinavir, a drug used to treat HIV.To avoid gastrointestinal upset, you should gradually introduce or increase the amount of garlic you consume.According to Consumer Reports, black garlic is aged under high heat and humidity for 10 days.Raw garlic is very pungent, which means your breath will likely stink for several hours after eating it.To combat this, you could reduce the amount of garlic you eat, use probiotics for optimal gut health or try adding good smelling herbs to your diet.According to the Cleveland Clinic, you may also experience a stinging feeling on your hands from handling raw or powdered garlic.To avoid the potential of developing skin lesions where you came in contact with the garlic, they recommend wearing protective gloves. .
Garlic Uses, Side Effects & Warnings
Garlic is an herb also known as Ail, Ajo, Allii Sativi Bulbus, Allium, Allium sativum, Camphor of the Poor, Da Suan, Lasun, Lasuna, Nectar of the Gods, Poor Man's Treacle, Rason, Rust Treacle, or Stinking Rose.When used as a food product, garlic is not likely to produce health benefits or side effects.When used as a medicinal product, garlic may produce both desired and unwanted effects on the body.Garlic has also been used to treat high cholesterol, stomach ulcers caused by H. pylori, cancer, or circulation problems in the legs.Other uses not proven with research have included preventing the common cold, and improving urination problems caused by an enlarged prostate.There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs.Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.The use of garlic as a flavoring agent in foods is considered safe during pregnancy.Do not use different forms (cloves, tablets, oil, etc) of garlic at the same time without medical advice.Call your doctor if the condition you are treating with garlic does not improve, or if it gets worse while using this product.If you need surgery, dental work, or a medical procedure, stop taking garlic at least 2 weeks ahead of time.Store at room temperature away from moisture, heat, and light, or as directed on the package.This includes angelica (dong quai), capsicum, clove, danshen, ginger, ginkgo, horse chestnut, panax ginseng, poplar, red clover, turmeric, and willow.Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.Although not all side effects are known, garlic is thought to be possibly safe when taken for a short period of time.Common side effects (especially when eating raw garlic) may include:.Other drugs may affect garlic, including prescription and over-the-counter medicines, vitamins, and herbal products.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
10 harmful effects of garlic that you should know
Garlic is a common cooking ingredient used in every Indian household to enhance the flavour of food. .