Warfarin is a blood-thinning medication that helps treat and prevent blood clots.However, certain foods and beverages can make warfarin less effective in preventing blood clots.The adequate intake level of vitamin K for adult men is 120 micrograms (mcg).Certain drinks can increase the effect of warfarin, leading to bleeding problems.Avoid or consume only small amounts of these drinks when taking warfarin:.Talk to your doctor before making any major changes in your diet and before starting any over-the-counter medications, vitamins or herbal supplements.If you are unable to eat for several days or have ongoing stomach upset, diarrhea or fever, consult your doctor. .
Study: Leafy Greens OK For People on Warfarin
A new study suggests that -- despite doctor warnings to the contrary -- you can eat leafy greens rich in vitamin K if you are taking the blood thinner warfarin. .
Warfarin and Vitamin K
To ensure that warfarin is effectively thinning your blood, it's important to eat about the same amount of vitamin K every day.Warfarin works against vitamin K, making your blood clot more slowly.If you want to start eating more of a food that's rich in vitamin K, talk to your doctor about how to add it safely.To find out how well warfarin is working, you will get blood tests to measure how long it takes for your blood to clot.A low INR means that warfarin isn't working well enough to prevent a dangerous blood clot.A low INR means that warfarin isn't working well enough to prevent a dangerous blood clot.Keeping your warfarin and vitamin K intake steady every day helps keep you in a safe INR range. .
Warfarin, your diet, and vitamin K foods
Some foods you eat affect the way warfarin works in your body.It is most important to eat a healthy, consistent, and balanced diet.Keep your diet of foods high in vitamin K about the same.The most common foods that have high vitamin K are green leafy vegetables such as kale, collard greens, broccoli, spinach, cabbage, and lettuce.All foods are okay, but do not make big changes to how much or what you eat.It is important to check with your health-care provider before making any big changes to your diet. .
Diet and Warfarin: What You Need to Know
It’s used to prevent blood clots from forming in your blood vessels.Although there is no specific “warfarin diet,” certain foods and drinks can make warfarin less effective.Warfarin interferes with the way a certain clotting factor helps your blood to clot.Without enough vitamin K to use, the vitamin K-dependent clotting factor can’t help your blood to clot like it usually does.Your body makes vitamin K, but it also gets it from certain foods you eat.One way you can help warfarin work its best is by avoiding big changes in the amount of vitamin K you get through food.Foods to limit while taking warfarin If you suddenly start eating foods that have more vitamin K while you take warfarin, you may make warfarin less effective.Chard You should also avoid drinking: Green tea.Alcohol Green tea contains vitamin K and could lower the effectiveness of warfarin.Drinking grapefruit juice, cranberry juice, and alcohol during treatment with warfarin can increase your risk of bleeding.Some vegetables and fruits low in vitamin K include: Sweet corn. .
Consistency, Not Avoidance: The Truth About Blood Thinners, Leafy
If you take blood thinners, chances are you've heard that certain foods—like leafy greens—can cause potentially dangerous food-drug interactions."I get a lot of patients who come to me and say, 'I was told to avoid these foods because they interfere with my medication'," says Fran Burke MS, RD, a clinical dietitian in the Preventive Cardiovascular Program at Penn Medicine.Warfarin (the generic version of Coumadin) is the most widely used blood thinner that works by blocking a vitamin K-dependent step in clotting factor production. .
Spinach: Health Benefits, Side Effects, Uses, Dose & Precautions
View abstract.View abstract.Int J Food Sci Nutr 2005;56(7):473-481.View abstract.View abstract.Bakshi, S., Bergman, M., Dovrat, S., and Grossman, S. Unique natural antioxidants (NAOs) and derived purified components inhibit cell cycle progression by downregulation of ppRb and E2F in human PC3 prostate cancer cells.View abstract.Bengmark, S.
and Gianotti, L. Nutritional support to prevent and treat multiple organ failure.View abstract.Berson, E.
L. Nutrition and retinal degenerations.View abstract.Betsche, T. and Fretzdorff, B.
Biodegradation of oxalic acid from spinach using cereal radicles.View abstract.View abstract.Bohn, T., Davidsson, L., Walczyk, T., and Hurrell, R. F. Fractional magnesium absorption is significantly lower in human subjects from a meal served with an oxalate-rich vegetable, spinach, as compared with a meal served with kale, a vegetable with a low oxalate content.View abstract.View abstract.View abstract.View abstract.Cao, G., Russell, R.
M., Lischner, N., and Prior, R. L. Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women.View abstract.View abstract.Charatan, F.
FDA warns US consumers not to eat spinach after E coli outbreak.View abstract.View abstract.Chitchumroonchokchai, C., Schwartz, S. J., and Failla, M. L. Assessment of lutein bioavailability from meals and a supplement using simulated digestion and caco-2 human intestinal cells.View abstract.View abstract.View abstract.E. coli O157:H7 outbreak in the United States associated with bagged fresh spinach.View abstract.View abstract.View abstract.View abstract.View abstract.Fruit polyphenolics and brain aging: nutritional interventions targeting age-related neuronal and behavioral deficits.Garber, A. K., Binkley, N.
C., Krueger, D. C., and Suttie, J.
W. Comparison of phylloquinone bioavailability from food sources or a supplement in human subjects.Goldbohm, R.
A., Brants, H. A., Hulshof, K. F., and van den Brandt, P. A.The contribution of various foods to intake of vitamin A and carotenoids in The Netherlands.A., Molloy, A.
M., Kerr, M. A., and McNulty, H. Determining bioavailability of food folates in a controlled intervention study.He, T., Huang, C. Y., Chen, H., and Hou, Y.
H. Effects of spinach powder fat-soluble extract on proliferation of human gastric adenocarcinoma cells.Heaney, R.
P., Weaver, C. M., and Recker, R. R.
Calcium absorbability from spinach.The influence of dietary factors on the risk of urinary stone formation.Hora, R., Warriner, K., Shelp, B. J., and Griffiths, M.
W. Internalization of Escherichia coli O157:H7 following biological and mechanical disruption of growing spinach plants.Jablasone, J., Warriner, K., and Griffiths, M. Interactions of Escherichia coli O157:H7, Salmonella typhimurium and Listeria monocytogenes plants cultivated in a gnotobiotic system.Am J Clin Nutr 2005;81(1 Suppl):313S-316S.Kato, M. [Oxalate loading test for outpatients with calcium oxalate stones].Spinach cultigen variation for tissue carotenoid concentrations influences human serum carotenoid levels and macular pigment optical density following a 12-week dietary intervention.Kubler, W.
[Methemoglobinemia caused by spinach in infancy].Int J Food Microbiol 7-20-2001;67(1-2):153-155.Kuriyama, I., Musumi, K., Yonezawa, Y., Takemura, M., Maeda, N., Iijima, H., Hada, T., Yoshida, H., and Mizushina, Y. Inhibitory effects of glycolipids fraction from spinach on mammalian DNA polymerase activity and human cancer cell proliferation.Food Addit.Contam 2002;19(6):524-532.Effect of dietary oxalate and calcium on urinary oxalate and risk of formation of calcium oxalate kidney stones.McKillop, D.
J., McNulty, H., Scott, J. M., McPartlin, J.
M., Strain, J. J., Bradbury, I., Girvan, J., Hoey, L., McCreedy, R., Alexander, J., Patterson, B.
K., Hannon-Fletcher, M., and Pentieva, K. The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation.McKillop, D. J., Pentieva, K. D., Scott, J. M., Strain, J. J., McCreedy, R., Alexander, J., Patterson, K., Hughes, J., and McNulty, H.
Protocol for the production of concentrated extracts of food folate for use in human bioavailability studies.The potential role of dietary xanthophylls in cataract and age-related macular degeneration.Muller, H., Bub, A., Watzl, B., and Rechkemmer, G. Plasma concentrations of carotenoids in healthy volunteers after intervention with carotenoid-rich foods.A European carotenoid database to assess carotenoid intakes and its use in a five-country comparative study.Ongoing multistate outbreak of Escherichia coli serotype O157:H7 infections associated with consumption of fresh spinach--United States, September 2006.Pingulkar, K., Kamat, A., and Bongirwar, D. Microbiological quality of fresh leafy vegetables, salad components and ready-to-eat salads: an evidence of inhibition of Listeria monocytogenes in tomatoes.Int.J Food Sci.Nutr.Porrini, M., Riso, P., and Oriani, G. Spinach and tomato consumption increases lymphocyte DNA resistance to oxidative stress but this is not related to cell carotenoid concentrations.Prinz-Langenohl, R., Bronstrup, A., Thorand, B., Hages, M., and Pietrzik, K.
Availability of food folate in humans.Reddy, M. K., Alexander-Lindo, R. L., and Nair, M. G.
Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors.Riso, P., Brusamolino, A., Ciappellano, S., and Porrini, M. Comparison of lutein bioavailability from vegetables and supplement.Allergy 1997;52(12):1245-1246.Savino, F., Maccario, S., Guidi, C., Castagno, E., Farinasso, D., Cresi, F., Silvestro, L., and Mussa, G. C.
Methemoglobinemia caused by the ingestion of courgette soup given in order to resolve constipation in two formula-fed infants.Allergy 2005;60(3):408-409.Effect of food matrix on circulating vitamin K concentrations.Simon, C. [Poisoning by nitrites after ingestion of spinach (a form of methemoglobinemia)].Smeenk, C.
and van Oudheusden, A. P.
[Hemoglobinemia caused by spinach water].The FDA: fresh leafy greens grown in the United States are safe.Torres-Sanchez, L., Lopez-Carrillo, L., Lopez-Cervantes, M., Rueda-Neria, C., and Wolff, M. S. Food sources of phytoestrogens and breast cancer risk in Mexican women.Food Microbiol.Diet and stomach cancer in Korea.Int J Cancer 1997;Suppl 10:7-9.Blomhoff, R. Dietary antioxidants and cardiovascular disease.Chasan-Taber L, Willett WC, Seddon JM, et al.
A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women.Lutein bioavailability is higher from lutein-enriched eggs than from supplements and spinach in men.[Allergy to Chenopodiaceae (beets, spinach) associated with latex allergy].Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits.Karlson, B., Leijd, B., and Hellstrom, K. On the influence of vitamin K-rich vegetables and wine on the effectiveness of warfarin treatment.Maillard, H., Lemerle, E., Garot, D., Leclech, C., and Machet, L. [Crossed spinach-latex allergy revealed by exercise-induced anaphylaxis].Seddon JM, Ajani UA, Sperduto R, et al.
Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. .
Blood Thinners and Greens: A Mix to Avoid? How to Eat Well for
You might have heard that if you take an anticoagulant (blood thinner), like Coumadin (warfarin), you should stop eating, or at least eat fewer, green vegetables, because they contain too much Vitamin K. But is this really the case?Firstly, it’s important to note that Coumadin (generic name: warfarin) is an anticoagulant, which means it stops the formation of blood clots and makes blood thinner (less viscous).Other factors include genetics, diet, adherence to treatment and other medications you may be taking.Now that we’re reviewed some basic facts, let’s get to the nitty gritty: diet and its effect on medication!Several vegetables, particularly green ones, contain Vitamin K, in varying quantities.Two main reasons can explain why reducing your intake of green vegetables is not necessary, even if you’re going through anticoagulation therapy.Indeed, regularly eating vegetables, particularly green ones, helps you to be less sensitive to daily variations in Vitamin K.
This is explained by the fact the liver stocks some Vitamin K, because it is a fat soluble vitamin.However, if you never eat green vegetables, you don’t have Vitamin K stores, so if you eat a good amount of green vegetables one day, you’ll experience a “peak” of Vitamin K, which will then destabilize your INR.What’s more, we only know the Vitamin K content of around half the food in the North American diet.For these reasons, we recommend an intake of 1 to 2 portions of green vegetables each day, even for those taking Coumadin. .
Medication Interactions: Food, Supplements and Other Drugs
But even healthy foods, including fruits and vegetables, can cause unintended and possibly dangerous interactions with certain medications.Their high vitamin K levels pose risks for patients being treated with *blood thinners to prevent strokes.It comes down to maintaining a careful balance when using anti-coagulants such as Coumadin (also known generically as warfarin and marketed under the brand names Marevan, Lawarin, Waran and Warfant).Dr. Gandy said food isn’t the only thing to be cautious of when taking blood thinners, also called anticoagulants.On the flip side, some over-the-counter medications used to treat cold and allergy symptoms can cause the blood thinners to have more potent effects.In the case of statin-based cholesterol medications, including those marketed under brands such as Lipitor, Mevacor and Zocor, grapefruit and pomegranate can be a dangerous mix.And even simple things like salt, which is widespread in the food supply can take a toll because it increases the amount of fluid retained in the body, rendering the medication dose inadequate.The key for cardiovascular disease patients is to be aware of the risks and maintain regular communication with healthcare providers, Dr.
Gandy said.In fact, eating chocolate and taking MAO inhibitors such as Nardil (phenelzine) or Parnate (tranylcypromine) for depression could be dangerous.Don’t drink grapefruit juice with certain blood pressure-lowering drugs because it can cause higher levels of those medicines in your body, making side effects more likely.St. John’s Wort (Hypericum perforatum): This herb is an inducer of liver enzymes, which means it can reduce the concentration of medications in the blood.In addition, ginseng can enhance the bleeding effects of heparin, aspirin and nonsteroidal anti-inflammatory drugs such as ibuprofen, naproxen and ketoprofen.Combining ginseng with MAO inhibitors such as Nardil or Parnate may cause headaches, trouble sleeping, nervousness and hyperactivity.If you are taking sedatives, tranquilizers or a prescription drug for high blood pressure or depression, you should check with a doctor or pharmacist before you start using antihistamines.Bronchodilators: These drugs temporarily relieve shortness of breath, tightness of chest and wheezing due to bronchial asthma. .